Cytokines sing the blues: inflammation and the pathogenesis of depression.
Explore this paper's citation graph
Summary
These findings suggest that targeting proinflammatory cytokines and their signaling pathways might represent a novel strategy to treat depression.
- Type
- review
- Published
- 2006-01-01
- Cited by
- 3,012
- References
- 100
- Access
- Open access
- OpenAlex
- https://openalex.org/W2097740790
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6226469
Keywords
Proinflammatory cytokine, Inflammation, Chemokine, Sickness behavior, Cytokine
References
- Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
- Anterior cingulate activation and error processing during interferon-alpha treatment.
- Major depression and activation of the inflammatory response system.
- Textbook of psychopharmacology
- Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
- Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress.
- Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis.
- Neurobehavioral Effects of Interferon-α in Cancer Patients: Phenomenology and Paroxetine Responsiveness of Symptom Dimensions
- Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders.
- Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways.
- Changes in acute-phase proteins during lithium potentiation of antidepressants in refractory depression.
- Gene regulation and DNA damage in the ageing human brain
- Herpes Viruses, Cytokines, and Altered Hemostasis in Vital Exhaustion
- Inflammation-associated cancer: NF-kappaB is the lynchpin.
- Functional improvement in heart failure patients treated with beta-blockers is associated with a decline of cytokine levels.
- Clinical depression and inflammatory risk markers for coronary heart disease.
- Cytokine Production and Treatment Response in Major Depressive Disorder
- Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey.
- Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome
- Chronic beta-adrenergic stimulation induces myocardial proinflammatory cytokine expression.
Cited by
- Metabolic syndrome, activity of the hypothalamic-pituitary-adrenal axis and inflammatory mediators in depressive disorder.
- 主観的幸福感に着目した心身相関の新展開(シンポジウム:Neuroimagingの新展開,2010年,第51回日本心身医学会総会ならびに学術講演会(仙台))
- Depressive symptoms and production of proinflammatory cytokines by peripheral blood mononuclear cells stimulated in vitro.
- Therapy of interferon-induced depression in chronic hepatitis C with citalopram: a randomised, double-blind, placebo-controlled study
- Polycystic ovary syndrome, depression, and affective disorders.
- Inflammatory biomarkers in 70 depressed inpatients with and without the metabolic syndrome.
- Increased plasma d-lactic acid associated with impaired memory in rats.
- A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression.
- Endocannabinergic Modulation of Interleukin-1β in Mouse Hippocampus under Basal Conditions and after in vivo Systemic Lipopolysaccharide Stimulation
- Biomarkers of PTSD: neuropeptides and immune signaling.
- Benefits on quality of life concomitant to metabolic improvement in intervention program for prevention of diabetes mellitus
- Living well with medical comorbidities: a biopsychosocial perspective.
- Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression
- An intricate relationship between pain and depression: clinical correlates, coactivation factors and therapeutic targets
- DIETARY RESTRICTION REVERSES OBESITY-INDUCED ANHEDONIA
- Putative Transcriptomic Biomarkers in the Inflammatory Cytokine Pathway Differentiate Major Depressive Disorder Patients from Control Subjects and Bipolar Disorder Patients
- Methylene Blue Attenuates Traumatic Brain Injury-Associated Neuroinflammation and Acute Depressive-Like Behavior in Mice
- Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction.
- The organization of the stress system and its dysregulation in depressive illness
- Perineal Injury During Childbirth Increases Risk of Postpartum Depressive Symptoms and Inflammatory Markers
Related papers
- Maternal inhibition of infant behavioral response following isolation in novel surroundings and Inflammatory challenge
- Neonatal stress modulates sickness behavior: role for proinflammatory cytokines.
- Sulforaphane reduces lipopolysaccharide-induced proinflammatory markers in hippocampus and liver but does not improve sickness behavior
- The possible role of cytokines in chemotherapy-induced cognitive deficits.
- Ecklonia cava Extract Exerts Anti-Inflammatory Effect in Human Gingival Fibroblasts by Suppression of Proinflammatory Cytokines and Chemokines
- Effects of prior stress on LPS-induced cytokine and sickness responses.
- The significance of proinflammatory cytokines and Th1/ Th2 balance in depression and action of antidepressants
- Cytokine production profile of early thymocytes and the characterization of a new class of chemokine
- Role of Proinflammatory Cytokines on Lipopolysaccharide-Induced Phase Shifts in Locomotor Activity Circadian Rhythm