Brain-Derived Neurotrophic Factor (BDNF) Induces Dendritic Targeting of BDNF and Tyrosine Kinase B mRNAs in Hippocampal Neurons through a Phosphatidylinositol-3 Kinase-Dependent Pathway
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Summary
Because most hippocampal neurons coexpress BDNF and TrkB receptors, these results show that the subcellular distribution of BDNF–TrkB mRNAs is under the control of an autocrine–paracrine BDNF-TrkB-dependent loop.
- Type
- article
- Published
- 2000-05-01
- Cited by
- 129
- References
- 89
- Access
- Open access
- OpenAlex
- https://openalex.org/W2097557124
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31064050
Keywords
Tropomyosin receptor kinase B, Brain-derived neurotrophic factor, Neurotrophic factors, Hippocampal formation, Neuroscience
References
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- Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions
- Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
- RNA, Whither Goest Thou?
- Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes
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- Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.
- Neurotrophin-evoked rapid excitation through TrkB receptors
- Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
- Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non‐NMDA glutamate receptors.
- Dendritic and postsynaptic localizations of glycine receptor alpha subunit mRNAs.
- Differential Effects of Protein Synthesis Inhibition on the Activity-Dependent Expression of BDNF Transcripts: Evidence for Immediate-Early Gene Responses from Specific Promoters
- Lamina-Specific Synaptic Activation Causes Domain-Specific Alterations in Dendritic Immunostaining for MAP2 and CAM Kinase II
- trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors
- Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus.
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- Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
Cited by
- Ca2+-dependent Regulation of TrkB Expression in Neurons*
- Expression of TrkB Receptors in Developing Visual Cortex Is Not Regulated by Light
- The role of muscle-synthesized brain-derived neurotrophic factor (BDNF) in the health and maintenance of motorneurons
- BDNF and synaptic plasticity, cognitive function, and dysfunction.
- Neurotrophins and cortical development.
- Does Environmental Enrichment Exposure Prior to Injury Influence Biomarkers Associated with Chronic Stage TBI
- ROLE OF DENDRITIC BDNF SYNTHESIS IN ADULT NEUROGENESIS AND SPINE MORPHOGENESIS
- Neurotrophic Theory of Accelerated Temporal Cortex Maturation in the Valproic Acid Rat Model of Autism
- Transport und Translation der dendritisch lokalisierten shank1-mRNA in Rattus norvegicus (Berkenhout, 1769)
- Two cis-acting elements in the 3′ untranslated region of α-CaMKII regulate its dendritic targeting
- Adaption of the serotoninergic neuronal phenotype in the absence of 5‐HT autoreceptors or the 5‐HT transporter: involvement of BDNF and cAMP
- Apolipoprotein E mRNA is transported to dendrites and may have a role in synaptic structural plasticity
- Neurotrophins and neuronal plasticity in the action of antidepressants and morphine
- Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
- Role of brain-derived neurotrophic factor and NF-κB in neuronal plasticity and survival: From genes to phenotype
- Mecanismos intracelulares de supervivencia y muerte neuronal en modelos excitotóxicos y transgénicos de la enfermedad de Huntington.
- Getting the message across: the intracellular localization of mRNAs in higher eukaryotes.
- Up‐regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B‐dependent mechanisms
- Truncated TrkB: beyond a dominant negative receptor.
- Rapid up‐regulation of the neuronal serotoninergic phenotype by brain‐derived neurotrophic factor and cyclic adenosine monophosphate: Relations with raphe astrocytes
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