Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

Keywords

Pleckstrin homology domain, Cell biology, Phosphatidylinositol, Kinase, Protein kinase B

References

• Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocationBentley Cheatham, Chris J. Vlahos, Lynn Cheatham — 1994
• Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activationW G King, Mark D. Mattaliano, Tung O. Chan — 1997
• A Constitutively Active Version of the Ser/Thr Kinase Akt Induces Production of the obGene Product, Leptin, in 3T3-L1 Adipocytes.Andreas Barthel, Aimee D. Kohn, Yanan Luo — 1997
• A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like regionAlfonso Bellacosa, Testa, SP Staal — 1991
• Apoptosis Meets Signal Transduction: Elimination of a BAD InfluenceThomas F. Gajewski, Craig B. Thompson — 1996

Cited by

• Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.Marta Salinas, Raquel López‐Valdaliso, Daniel Martı́n — 2000
• Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo이승지 — 2000
• Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes.Michelle Foss — 2000
• Kinase pathways in dominant and subordinate ovarian follicles during the first wave of follicular development in sheep.Vaiva KalnikaitO, Steve Whittaker, Regent Court — 2000
• Roles of Phosphatidylinositol 3-Kinase in Interferon-γ-dependent Phosphorylation of STAT1 on Serine 727 and Activation of Gene Expression*Hannah Nguyen, Chilakamarti V. Ramana, Joshua Bayes — 2001
• Abnormal T Cell Receptor Signal Transduction of CD4 Th Cells in X-Linked Lymphoproliferative Syndrome1まこ さいき — 2001
• Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells.P.K. Sandell, Jogeshwar Mukherjee, Sopan Das — 2001
• Regulation of the PRL promoter by Akt through cAMP response element binding protein.Amit Misra, János Sztipanovits, Gábor Karsai — 2002
• Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.明子 寺本, Teramoto Akiko — 2002
• Overexpression of α7 nicotinic acetylcholine receptor prevents G1‐arrest and DNA fragmentation in PC12 cells after hypoxia優美 及川 — 2002
• Regulation of rat Sertoli cell function by FSH: possible role of phosphatidylinositol 3-kinase/protein kinase B pathway.Silvina Beatriz Meroni, María Fernanda Riera, Eliana Herminia Pellizzari — 2002
• Factors contributing to autoimmune disease.Kristine M. Garza, Linh T. Nguyen, Russell G. Jones — 2001
• Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a phosphatidylinositol 3‐kinase (PI3) kinase‐dependent manner in Neuro2a cells善夫 太田, 隆夫 近村, 忠夫 米田 — 2003
• Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.Anna-Bettina Kaiser — 2005
• Modulation of the L-arginine/nitric oxide signalling pathway in vascular endothelial cells.史朗 中島, 義郎 波多野, 洋一 新井野 — 2004
• Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase.Russel Lawrence Barsh — 2005
• Adipocytes, myofibers, and cytokine biology: new horizons in the regulation of growth and body composition.Jeffrey C. Joe — 2006
• Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel Phosphatidylinositol 3-Kinase-dependent AKT/IκB Kinase α Pathway Targeting Activator Protein-1*Mohammad Nazrul Islam — 2008
• Possible Involvement of Phosphatidylinositol 3-Kinase, but Not Protein Kinase B or Glycogen Synthase Kinase 3β, in Progesterone-Induced Oocyte Maturation in the Japanese Brown Frog, Rana japonicaHumberto Juan Gosálbez Pequeño — 2008
• Stimulation of Glucose Uptake and Improvement of Insulin Resistance by AromadendrinYoshiro Tanizaki, Hikaru Kitani, Takashi Mifune — 2011

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