Metastasis suppressors alter the signal transduction of cancer cells
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Summary
Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified.
- Type
- review
- Published
- 2003-01-01
- Cited by
- 546
- References
- 108
- OpenAlex
- https://openalex.org/W2094964650
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24432370
Keywords
Metastasis, Signal transduction, Cancer research, Metastasis suppressor, Suppressor
References
- The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54*
- Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways
- Pharmacological importance of phospholipase D and phosphatidic acid in the regulation of the mitogen-activated protein kinase cascade.
- Effects of all-trans retinoic acid and epidermal growth factor on the expression of nm23-H1 in human hepatocarcinoma cells
- Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity.
- Critical steps in hematogenous metastasis: an overview.
- Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (Nm23)
- MKK4 and metastasis suppression: A marriage of signal transduction and metastasis research
- Molecular biology of breast cancer metastasis: Clinical implications of experimental studies on metastatic inefficiency
- MMTV-associated transcription factor binding sites increase nm23-H1 metastasis suppressor gene expression in human breast carcinoma cell lines
- Vitamin D3 Up-Regulated Protein 1 Mediates Oxidative Stress Via Suppressing the Thioredoxin Function1
- Two isotypes of murine nm23/nucleoside diphosphate kinase, nm23-M1 and nm23-M2, are involved in metastatic suppression of a murine melanoma line.
- Rho GTPases in transformation and metastasis.
- Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases.
- Analysis of mechanisms underlying BRMS1 suppression of metastasis
- Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells.
- Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition.
- Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers.
- Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor
- The relationship between nm23, angiogenesis, and the metastatic proclivity of node-negative breast cancer.
Cited by
- Host genetics and tumour metastasis
- The Molecular Signature of Metastases of Human Hepatocellular Carcinoma
- Effector memory T cells, early metastasis, and survival in colorectal cancer.
- Chemokines, chemokine receptors, and cancer metastasis
- Control of cell migration: a tumour suppressor function for p53?
- The role of protein geranylgeranylation in prostate cancer
- G-protein-coupled receptors and cancer
- New pharmacological strategies against metastatic spread
- 1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] suppresses pro-inflammatory responses by blocking NF-κB and MAPK signaling pathways in activated microglia.
- The inference of breast cancer metastasis through gene regulatory networks
- Tumor Heterogeneity: Mechanisms and Bases for a Reliable Application of Molecular Marker Design
- The current role of circulating tumor cells in the diagnosis and management of bone metastases in advanced prostate cancer.
- The faces and friends of RhoGDI2
- Rol de los receptores activadores de la proliferación de peroxisomas del subtipo gamma el el cáncer de vejiga
- miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma
- Scutellarin inhibits hypoxia‐induced epithelial‐mesenchymal transition in bladder cancer cells
- Analyzing Mechanisms of Metastatic Cancer Cell Adhesive Phenotype Leveraging Preparative Adhesion Chromatography Microfluidic
- Raman microspectroscopy, atomic force microscopy, and electric cell-substrate impedance sensing for characterization of bio-interfaces: Molecular, bacteria, and mammalian cells
- Metastasis of hormone receptor positive breast cancer.
- MOLECULAR MECHANISMS BY WHICH c- ABL AND ARG MEDIATE MELANOMA INVASION AND METASTASIS
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