Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients
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Summary
Low MLKL expression was significantly associated with both decreased DFS and OS in patients with primary ovarian cancer and may serve as a potential prognostic marker in patientsWith ovarian cancer, mixed lineage kinase domain-like protein is a key receptor interacting protein 3 downstream component of tumor-necrosis-factor-induced necrosis.
- Type
- article
- Published
- 2013-10-30
- Cited by
- 111
- References
- 24
- Access
- Open access
- OpenAlex
- https://openalex.org/W2094396436
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4218696
Keywords
Ovarian cancer, Immunohistochemistry, Proportional hazards model, Medicine, Internal medicine
References
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- Pronecrotic Mixed Lineage Kinase Domain-Like Protein Expression Is a Prognostic Biomarker in Patients With Early-Stage Resected Pancreatic Adenocarcinoma
- Prognostic role of c-Jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan.
- DNA damage induces two distinct modes of cell death in ovarian carcinomas
- Many stimuli pull the necrotic trigger, an overview
- Overexpression of c-Abl predicts unfavorable outcome in epithelial ovarian cancer.
- Prognostic value of centromere protein-A expression in patients with epithelial ovarian cancer
- Rethinking Ovarian Cancer: Recommendations for Improving Outcomes
- The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.
- Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells
- Current status of gynecological cancer in China.
- TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.
- Necrotic death as a cell fate.
- Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
- Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
- Molecular mechanisms of necroptosis: an ordered cellular explosion
- Cancer statistics, 2013
- First-Line Therapy in Ovarian Cancer Trials
Cited by
- Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
- Molecular mechanisms of regulated necrosis.
- Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma.
- Cancer and necroptosis: friend or foe?
- Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.
- An outline of necrosome triggers
- HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
- Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas.
- Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancer.
- Necroptosis: Mechanisms and Relevance to Disease
- Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer
- Prognostic value of mixed lineage kinase domain-like protein expression in the survival of patients with gastric caner
- Relevance of necroptosis in cancer
- Necroptosis and Cancer
- Initiation and execution mechanisms of necroptosis: an overview
- Proteolytic control of regulated necrosis.
- Cationic liposome co-encapsulation of SMAC mimetic and zVAD using a novel lipid bilayer fusion loaded with MLKL-pDNA for tumour inhibition in vivo
- Necroptosis in cancer: An angel or a demon?
- The degradation of mixed lineage kinase domain-like protein promotes neuroprotection after ischemic brain injury
- mRNA expression profiles obtained from microdissected pancreatic cancer cells can predict patient survival
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