Focal Adhesion Kinase Activated by β4 Integrin Ligation to mCLCA1 Mediates Early Metastatic Growth*

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Summary

It is shown that lung colonization by B16-F10 cells is licensed by β4 integrin adhesion to the mouse lung endothelial Ca2+-activated chloride channel protein mCLCA1, which is associated with FAK complexing, activation, and signaling to promote early, intravascular, metastatic growth.

Type
article
Published
2002-09-13
Cited by
121
References
44
Access
Open access

Keywords

Focal adhesion, Integrin, Ligation, Cancer research, Adhesion

References

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