Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats
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Summary
The results indicate that the VTA dopamine neuronal activity is reduced during the first day of nicotine withdrawal, which is found to be significantly decreased after the last nicotine administration.
- Type
- article
- Published
- 2004-06-28
- Cited by
- 42
- References
- 21
- OpenAlex
- https://openalex.org/W2092822643
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9080783
Keywords
Ventral tegmental area, Dopamine, Nicotine, Premovement neuronal activity, Nicotine withdrawal
References
- The rat brain in stereotaxic coordinates: Authors: George Paxinos & Charles Watson Academic Press Australia, 1982 Softback, 154 pages (including 71 plates), 35.00 Aust $
- Dramatic decreases in brain reward function during nicotine withdrawal
- Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.
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- Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens
- The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity
- Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
- Effects of nicotine withdrawal on central dopaminergic systems.
- Neurobiological mechanisms of nicotine craving.
- Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine
- Mecamylamine-precipitated nicotine-withdrawal aversion in rats.
- Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats.
- Nicotine modifies the activity of ventral tegmental area dopaminergic neurons and hippocampal GABAergic neurons.
- A comparison of the effects of nicotine on dopamine and non-dopamine neurons in the rat ventral tegmental area: an in vitro electrophysiological study.
- Action of nicotine on accumbens dopamine and attenuation with repeated administration.
- Nicotine withdrawal leads to increased firing rates of midbrain dopamine neurons
- Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome.
- Intracellular and extracellular electrophysiology of nigral dopaminergic neurons--1. Identification and characterization.
- Mesolimbic dopaminergic decline after cannabinoid withdrawal.
Cited by
- A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation
- Neural substrates of psychostimulant withdrawal-induced anhedonia.
- Rodent models of nicotine withdrawal syndrome.
- Identification of Pharmacological and Molecular Mechanisms involved in Nicotine Withdrawal
- Effects of chronic nicotine on behavioural and neurochemical responses to morphine
- Mecanismos motivacionales del Craving: ansia por el tabaco
- The dopamine hypothesis of drug addiction: hypodopaminergic state.
- Neural Mechanisms of Anxiety during Opiate Withdrawal: Role of the Ventral Tegmental Area and Extended Amygdala
- Beta2-containing nicotinic acetylcholine receptors mediate calcium/calmodulin-dependent protein kinase-II and synapsin I protein levels in the nucleus accumbens after nicotine withdrawal in mice
- Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement
- Anhedonia and Substance Dependence: Clinical Correlates and Treatment Options
- Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs
- Effects of calcium channel antagonists on the motivational effects of nicotine and morphine in conditioned place aversion paradigm.
- Role of α5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice
- Hippocampal nAChRs Mediate Nicotine Withdrawal-Related Learning Deficits
- The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence
- Nicotine-conditioned place preference induced CREB phosphorylation and Fos expression in the adult rat brain
- Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA
- Addiction is a Reward Deficit and Stress Surfeit Disorder
- Increased Dopamine Receptor Activity in the Nucleus Accumbens Shell Ameliorates Anxiety during Drug Withdrawal
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