Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats.
Explore this paper's citation graph
Summary
The results indicate that the mesolimbic and mesocortical dopamine system undergo opposite changes during mecamylamine-precipitated abstinence in rats chronically exposed to nicotine and that physical abstinence signs can be dissociated from changes in dopamine transmission.
- Type
- article
- Published
- 2000-02-01
- Cited by
- 102
- References
- 33
- OpenAlex
- https://openalex.org/W2025491101
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40260557
Keywords
Nucleus accumbens, Mecamylamine, Dopamine, Nicotine, Prefrontal cortex
References
- Major depression and stages of smoking. A longitudinal investigation.
- Dramatic decreases in brain reward function during nicotine withdrawal
- Nicotine activates and desensitizes midbrain dopamine neurons
- Major depression following smoking cessation.
- Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.
- Regional variation in the effects of nicotine on catecholamine overflow in rat brain.
- Depression and self-medication with nicotine: the modifying influence of the dopamine D4 receptor gene.
- Comorbidity between depressive disorders and nicotine dependence in a cohort of 16-year-olds.
- Nicotine self-administration in animals and humans: similarities and differences
- The neurobiology of tobacco addiction.
- Psychopharmacology: The Fourth Generation of Progress
- Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
- Raven Press, New York (1995)
- Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: comparison with caudate-putamen.
- Neurobiological Similarities in Depression and Drug Dependence: A Self-Medication Hypothesis
- A dopamine‐μ1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non‐psychostimulant drugs of abuse
- PHYSICAL ABSTINENCE SYNDROME IS DISSOCIATED FROM CHANGES IN EXTRACELLULAR DOPAMINE IN THE NUCLEUS ACCUMBENS AND IN THE PREFRONTAL CORTEX OF NICOTINE DEPENDENT RATS
- Cigarette smoking: implications for psychiatric illness.
- Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome
- Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence.
Cited by
- Nicotine dependence: studies with a laboratory model.
- The neuronal pathways mediating the behavioral and addictive properties of nicotine.
- Rodent models of nicotine withdrawal syndrome.
- Sensitization of cortical acetylcholine release by repeated administration of nicotine in rats
- Characterization of the behavioral and neurochemical effects of nicotine withdrawal in adolescent and adult rats
- Nicotine Addiction: Past and Present
- Identification of Pharmacological and Molecular Mechanisms involved in Nicotine Withdrawal
- Baclofen prevented the changes in c‐Fos and brain‐derived neutrophic factor expressions during mecamylamine‐precipitated nicotine withdrawal in mice
- Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration
- Effects of chronic nicotine on behavioural and neurochemical responses to morphine
- Nicotine withdrawal produces fewer decreases in extracellular levels of dopamine in the nucleus accumbens of adolescent versus adult rats.
- Effects of dopamine antagonists on drug cue-induced reinstatement of nicotine-seeking behavior in rats
- Mechanistic insights into nicotine withdrawal
- Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats
- Withdrawal from chronic nicotine in adolescent and adult rats.
- Inhibition of monoamine oxidase isoforms modulates nicotine withdrawal syndrome in the rat.
- Effect of prenatal stress on memory, nicotine withdrawal and 5HT1A expression in raphe nuclei of adult rats
- Neurodevelopmental liabilities of substance abuse
- Bupropion attenuates nicotine abstinence syndrome in the rat
- A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females
Related papers
- Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion.
- Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism
- An oral self-administration model of nicotine preference in rats: effects of mecamylamine
- Acute effects of nicotine injection into the nucleus accumbens on locomotor activity in nicotine-naive and nicotine-tolerant rats.
- Nicotinic Receptor-Mediated Reduction in l-DOPA-Induced Dyskinesias May Occur via Desensitization
- Behavioural effects of anatoxin, a potent nicotinic agonist, in rats.
- Characterization of Spontaneous and Precipitated Nicotine Withdrawal in the Mouse
- Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration.
- Mecamylamine-precipitated nicotine-withdrawal aversion in rats.
- Mecamylamine elicits withdrawal-like signs in rats following a single dose of nicotine