Clinical epidemiological quality in molecular genetic research: the need for methodological standards.
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Summary
Despite major laboratory advances in molecular genetic analysis, the data suggest that reported applications in clinical journals often have troubling omissions, deficiencies, and lack of attention to the different, but necessary, principles of clinical epidemiological science.
- Type
- article
- Published
- 1999-05-26
- Cited by
- 203
- References
- 127
- OpenAlex
- https://openalex.org/W2091619551
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2105510
Keywords
Medicine, Epidemiology, Clinical epidemiology, Molecular epidemiology, Objectivity (philosophy)
References
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- Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia.
- Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns.
- Mapping the human genome--friend or foe?
- Apolipoprotein E allele ∈4, dementia, and cognitive decline in a population sample
- Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancer.
- Genetic homogeneity between childhood-onset and adult-onset autosomal recessive spinal muscular atrophy.
- De-novo mutation and sporadic presentation of acute intermittent porphyria.
- Reduction of cellular rejection and increase in longer-term survival after heart transplantation after HLA-DR matching.
- How is the Human Genome Project doing, and what have we learned so far?
- The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal.
Cited by
- Methodology in diagnostic laboratory test research in clinical chemistry and clinical chemistry and laboratory medicine.
- The Quality of Meta-Analyses of Genetic Association Studies: A Review With Recommendations
- Poor-quality medical research: what can journals do?
- Methods Guide for Medical Test Reviews
- Toxicogenetics of Antiretroviral Therapy: Genetic Factors that Contribute to Metabolic Complications
- Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway.
- Prognoserelevanz von biologischen und molekularen Markern in der Onkologie
- Prognostic factors for epilepsy
- Studies on quantitative analysis and automatic recognition of cell types of lung cancer
- Second Edition:Three Generations in the Life of the Minnesota Women's Center: A History 1960-2000
- Evidence-Based Laboratory Medicine
- Genetic Determinants of Gastric Cancer
- Tumour banks: well-guarded treasures in the interest of patients
- Guías para un uso más eficiente de la información bioquímica
- Rules of evidence for cancer molecular-marker discovery and validation
- Automatic recognition of small cell carcinoma based on the self‐organizing neural network
- [The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting of observational studies].
- Periodontal epidemiology: towards social science or molecular biology?
- The systemic inflammatory response to cardiopulmonary bypass.
- Nature and nurture: the future of predictor variables
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