Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen.
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Summary
The absolute risk of DVT associated with these OCs seems to be especially high among carriers of the factor V Leiden mutation and among women with a family history of thrombosis, and the risk of carriers using the desogestrel-containing OC as compared with noncarrier non-users will be increased almost 50-fold.
- Type
- letter
- Published
- 1995-12-16
- Cited by
- 624
- References
- 14
- OpenAlex
- https://openalex.org/W1967108695
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36008719
Keywords
Desogestrel, Medicine, Factor V Leiden, Thrombophilia, Relative risk
References
- Low dose combined oral contraceptives
- Mutation in blood coagulation factor V associated with resistance to activated protein C
- Oral-contraceptive use in relation to myocardial infarction.
- Oral contraception and risk of a cerebral thromboembolic attack: results of a case-control study.
- Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.
- The natural history and epidemiology of venous thrombosis.
- Oral contraceptives and thromboembolic disease: effects of lowering oestrogen content.
- Oral contraceptives and venous thromboembolism: findings in a large prospective study.
- Thromboembolic Disease and the Steroidal Content of Oral Contraceptives. A Report to the Committee on Safety of Drugs
- Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study.
- Oral contraceptive estrogen dose and the risk of deep venous thromboembolic disease.
- New progestogens in oral contraception.
- EVALUATION OF A NEW GENERATION OF ORAL CONTRACEPTIVES
- The risk of deep venous thrombosis: a computerized epidemiologic approach.
Cited by
- Oral Contraception and the Risk of Thromboembolism
- Third generation oral contraception and venous thromboembolism
- Third-generation oral contraceptives and thromboembolism risk.
- Benefits and risks of oral contraceptives.
- Combined oral contraceptives, smoking, and cardiovascular risk.
- Budd-Chiari syndrome: combination of genetic defects and the use of oral contraceptives leading to hypercoagulability.
- The relationship between use of oral contraceptives and myocardial infarction in young women with fatal outcome, compared to those who survive: results from the MICA case-control study.
- Pulmonary embolism: what have we learned since Virchow? Natural history, pathophysiology, and diagnosis.
- Venous and arterial thrombosis during oral contraceptive use: risks and risk factors.
- Hereditary and Acquired Thrombophilia
- Hormonal contraception and risk of venous thromboembolism: national follow-up study
- Postmarketing study of ORTHO EVRA and levonorgestrel oral contraceptives containing hormonal contraceptives with 30 mcg of ethinyl estradiol in relation to nonfatal venous thromboembolism.
- Estrogen-Free Oral Hormonal Contraception: Benefits of the Progestin-Only Pill:
- Oral contraceptives and venous thromboembolism. A case-control study.
- Trends and patterns of hormonal contraceptive prescribing for adolescents in primary care in the UK
- Combined hormonal contraception and the risk of venous thromboembolism: a guideline.
- Oral Contraceptives and Venous Thromboembolism
- Activated protein C resistance--a major risk factor for thrombosis.
- Hormone-induced changes in the coagulation system
- Effect of Oral Contraceptives on Haemostasis Variables
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