Crypt stem cells as the cells-of-origin of intestinal cancer
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Summary
It is concluded that stem-cell-specific loss of Apc results in progressively growing neoplasia in long-lived intestinal stem cells.
- Type
- article
- Published
- 2009-01-29
- Cited by
- 2,213
- References
- 29
- OpenAlex
- https://openalex.org/W2090562908
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4422868
Keywords
LGR5, Stem cell, Cre recombinase, Biology, Crypt
References
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- The intestinal epithelial stem cell.
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- The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse.
- Cyclin D1 Is Not an Immediate Target of β-Catenin following Apc Loss in the Intestine*
- Phenotypic characterization of human colorectal cancer stem cells
- Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene
- The intestinal stem cell.
- Myc deletion rescues Apc deficiency in the small intestine
- Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Cited by
- Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer.
- Advances in Cancer Stem Cell Biology
- Paneth cells are also target of the ribotoxic lectin nigrin b.
- Stemming out of a new PML era?
- Colon cancer stem cells: promise of targeted therapy.
- Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways
- Defining the origins of Ras/p53-mediated squamous cell carcinoma
- A Quantitative Proteomic Approach of the Different Stages of Colorectal Cancer Establishes OLFM4 as a New Nonmetastatic Tumor Marker*
- The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.
- The tumor suppressor Apc controls planar cell polarities central to gut homeostasis
- Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells.
- Drosophila Rbp6 Is an Orthologue of Vertebrate Msi-1 and Msi-2, but Does Not Function Redundantly with dMsi to Regulate Germline Stem Cell Behaviour
- Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β
- Overlapping DNA Methylation Dynamics in Mouse Intestinal Cell Differentiation and Early Stages of Malignant Progression
- A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells.
- Review: US Spelling Colorectal cancer models for novel drug discovery
- A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
- Intestinal stem cells and inflammation.
- GUCY2C ligand replacement to prevent colorectal cancer
- The potential role of liver stem cells in initiation of primary liver cancer
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