Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Keywords

Phosphorylation, DNA-PKcs, Ionizing radiation, Ataxia-telangiectasia, Kinase

References

• DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.W. Kimryn Rathmell, William K. Kaufmann, John C. Hurt — 1997
• Dual roles of ATM in the cellular response to radiation and in cell growth control.Yang Xu, David Baltimore — 1996
• When is a lipid kinase not a lipid kinase? When it is a protein kinase.Tony Hunter — 1995
• DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2.Sheau-Yann Shieh, Masako Ikeda, Yoichi Taya — 1997
• A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.Michael B. Kastan, Qimin Zhan, Wafik S. El‐Deiry — 1992
• The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Kathleen S. Keegan, Douglas A. Holtzman, Annemieke W. Plug — 1996
• Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal formsDianne Watters, Kum Kum Khanna, Heather Beamish — 1997
• DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathwaysWilliam G. Nelson, Michael B. Kastan — 1994
• V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.Cynthia J. Guidos, Christine Williams, Ildiko Grandal — 1996
• Recombinant ATM protein complements the cellular A-T phenotypeYael Ziv, Anat Bar‐Shira, Iris Pecker — 1997
• Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathwaysCarrolee Barlow, Kevin D. Brown, Chu‐Xia Deng — 1997
• Mdm2 promotes the rapid degradation of p53Ygal Haupt, Ruth Maya, Anat Kazaz — 1997
• Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.Gregory J. Brunn, Christine C. Hudson, Aleksandar Sekulić — 1997
• Fragments of ATM which have dominant-negative or complementing activitySusan E. Morgan, Christine M. Lovly, Tej K. Pandita — 1997
• Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpointsWilliam A. Cliby, Christopher J. Roberts, Karlene A. Cimprich — 1998
• p53 and ATM: cell cycle, cell death, and cancer.Susan E. Morgan, Michael B. Kastan — 1997
• DNA damage induces phosphorylation of the amino terminus of p53.Janet D. Siliciano, Christine E. Canman, Yoichi Taya — 1997
• Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation.Timothy D. Shafman, Ahamed Saleem, John Kyriakis — 1995
• A single ataxia telangiectasia gene with a product similar to PI-3 kinase.Kinneret Savitsky, Anat Bar‐Shira, Shlomit Gilad — 1995
• The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.Christine E. Canman, Antonio C. Wolff, Chaw-Yuan Chen — 1994

Cited by

• Discovering inner ear and central auditory system cellular pathways that might contribute to age- related hearing lossXiaoxi Liu — 2011
• Oscillations by the p53-Mdm2 feedback loop.Galit Lahav — 2008
• Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2Mikko Härkönen, Riikka Vuokko, Päivi Mäkelä‐Bengs — 1999
• Cell cycle control, checkpoint mechanisms, and genotoxic stress.茂 北河 — 1999
• Regulation of p53 stabilityJacques Rouden — 1999
• The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.久雄 腰原 — 2000
• Study of the cytolethal distending toxin (CDT)‐activated cell cycle checkpoint晃 井上 — 2001
• ATM-dependent Phosphorylation of Human Rad9 Is Required for Ionizing Radiation-induced Checkpoint Activation*Didier Corderot — 2001
• Insights into cancer therapeutic design based on p53 and TRAIL receptor signalingLuis García de Oteyza — 2001
• Effects of hyperthermia on p53 protein expression and activity和子 大羽, 孝子 中垣 — 2002
• The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA.José López Arellano — 2002
• Ceramide and Reactive Oxygen Species Generated by H2O2 Induce Caspase-3-independent Degradation of Akt/Protein Kinase B*小宮山 智志 — 2002
• Role of tumor suppressors in DNA damage response.Bin‐Bing S. Zhou, Michael R. Mattern, Kum Kum Khanna — 2003
• Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.Àlvar Martínez Vidal, Antonio Adam Donat — 2004
• Melanoma cells express elevated levels of phosphorylated histone H2AX foci.Raoul Ν. Smith, William Frawley — 2005
• ATM signaling and 53BP1.Seongmin Kim, Sangsin Na — 2005
• Identification of Carboxyl-terminal MCM3 Phosphorylation Sites Using Polyreactive Phosphospecific Antibodies*Bernard Spodek — 2007
• ATM sequence variants associate with susceptibility to non‐small cell lung cancerSick — 2007
• ROLE OF ING2 (INHIBITOR OF GROWTH FAMILY MEMBER 2) IN CELLUAR RESPONSES TO DNA DAMAGEGuoming Sun — 2009
• Mathematical modeling of cell cycle regulation in response to DNA damage: Exploring mechanisms of cell-fate determination有紀 板倉 — 2011

Related papers

• Thyrotropin-stimulated phosphorylation of high mobility group protein 14 in vivo at the site catalyzed by cyclic nucleotide-dependent protein kinases in vitro.Gordon M. Walton, Gordon N. Gill, Edward C. Cooper — 1984
• Precision Substrate Targeting of Protein KinasesJason S. Wood, Xiongwei Yan, M. Mendelow — 1996
• Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinaseVladislava O. Melnikova, Annette B. Santamaria, Svetlana Bolshakov — 2003
• Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.David Cortez, Yi Wang, Jun Qin — 1999
• Constitutive phosphorylation of IcBa by casein kinase IICharlene F. Barroga, Jennifer K. Stevenson, Edward M. Schwarz — 2016
• Data from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing RadiationTom Stiff, Mark O’Driscoll, Nicole Rief — 2023
• Data from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing RadiationTom Stiff, Mark O’Driscoll, Nicole Rief — 2023
• Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.Gopal P. Sapkota, Mária Deák, Agnieszka Kieloch — 2002
• The role of ATM and ATR in DNA damage-induced cell cycle control.Aaron A. Goodarzi, Wesley D. Block, Susan P. Lees‐Miller — 2003
• ATM and ATR: sensing DNA damage.Jun Yang, Zhengping Xu, Yun Huang — 2004