Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
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Summary
Recent studies indicate that numerous components of the phosphatidylinositol-3-kinase (PI3K)/AKT pathway are targeted by amplification, mutation and translocation more frequently than any other pathway in cancer patients, with resultant activation of the pathway.
- Type
- review
- Published
- 2005-12-01
- Cited by
- 2,181
- References
- 191
- OpenAlex
- https://openalex.org/W2087861588
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3354107
Keywords
PI3K/AKT/mTOR pathway, Drug discovery, Protein kinase B, Chromosomal translocation, Cancer research
References
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- TOR, a central controller of cell growth.
- An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice
- The LKB1 tumor suppressor negatively regulates mTOR signaling.
- Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain.
Cited by
- IGF-I/IGFBP system: Metabolism outline and physical exercise
- Improving the response to molecular targeting of the TRAIL death receptors in colon cancer cells
- Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition
- Targeting the Phosphatidylinositol 3-Kinase Pathway in Airway Smooth Muscle
- Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells.
- Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
- Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer
- Are ER+PR+ and ER+PR- breast tumors genetically different? A CGH array study.
- Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules
- AKT-independent PI3-K signaling in cancer – emerging role for SGK3
- Targeting the PI3-kinase/Akt/mTOR Signaling Pathway
- The novel mTORC1/2 dual inhibitor INK-128 suppresses survival and proliferation of primary and transformed human pancreatic cancer cells.
- The effect of metformin treatment in vivo on acute and long-term energy metabolism and progesterone production in vitro by granulosa cells from women with polycystic ovary syndrome
- Silencing of COX-2 by RNAi modulates epithelial-mesenchymal transition in breast cancer cells partially dependent on the PGE2 cascade.
- Inhibition of 5-Lipoxygenase Selectively Triggers Disruption of c-Myc Signaling in Prostate Cancer Cells*
- Identification of signalling cascades involved in red blood cell shrinkage and vesiculation
- PI3K mutations in breast cancer: prognostic and therapeutic implications
- ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line
- Chapter 2: Molecular sensors based on fluorescence resonance energy transfer to visualize cellular dynamics.
- Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways.
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