Postburn constitutional changes in T-cell reactivity occur in CD8+ rather than in CD4+ cells.
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Summary
The data corroborate that major burn trauma will induce a significant shift of cytokine response toward the TH2 direction and demonstrate that the CD8+ rather than the CD4+ phenotype is the crucial cell for the polarization toward a TH2-driven immune response.
- Type
- article
- Published
- 1997-05-01
- Cited by
- 54
- References
- 34
- OpenAlex
- https://openalex.org/W2087607356
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2316812
Keywords
Reactivity (psychology), Cytotoxic T cell, Chemistry, Medicine, Pathology
References
- Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.
- IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.
- Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.
- Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.
- Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
- Role of interferons and other cytokines in the regulation of the immune response
- Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.
- The expanding universe of T-cell subsets: Th1, Th2 and more.
- Measurement of intracellular cytokines.
- Duration of postoperative immunosuppression assessed by repeated delayed type hypersensitivity skin tests.
- Head injury: an immunologic deficit in T-cell activation.
- Inadequate Interleukin 2 Production: A Fundamental Immunological Deficiency in Patients with Major Burns
- IL-12 at the crossroads.
- Abbreviated Injury Scale and Injury Severity Score: a scoring chart.
- Kinetics of interleukin-2 and interleukin-6 synthesis following major mechanical trauma.
- Immune regulation: a new role for the CD8+ T cell.
- Lymphocyte responses and cytokines.
- Type 1 and type 2: a fundamental dichotomy for all T-cell subsets.
- Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation
- Inadequate interleukin-2 synthesis and interleukin-2 messenger expression following thermal and mechanical trauma in humans is caused by defective transmembrane signalling.
Cited by
- Stress induced IL-10 does not seem to be essential for early monocyte deactivation following cardiac surgery.
- Cellular immunity after ethanol exposure and burn injury: dose and time dependence.
- Effects of aging on immune function.
- Evaluation of the immunity response in children with burns
- Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b+Gr-1+ Myeloid-Derived Suppressor Cells Require HMGB1
- Low CD8 T cells in neonates and infants prior to surgery, and health‐care‐associated infections: Prospective observational study
- Immunization of burn-patients with a Pseudomonas aeruginosa outer membrane protein vaccine elicits antibodies with protective efficacy.
- The Effects of Immunoglobulin Treatment Upon Th Polarization in Rats with Experimentally Induced Sepsis
- Altered Cell-mediated Immunity and Increased Postoperative Infection Rate in Long-term Alcoholic Patients
- Innate and adaptive immunity gene expression of human keratinocytes cultured of severe burn injury.
- Changes in Cytokine Levels and CD4+/CD8+ T Cells Ratio in Draining Lymph Node of Burn Wound
- Cimetidine effects on the immunosuppression induced by burn injury.
- Role of nitric oxide in depressed lymphoproliferative responses and altered cytokine production following thermal injury in rats.
- Insulin-like growth factor-I/insulin-like growth factor binding protein-3 alters lymphocyte responsiveness following severe burn.
- CD8(+) T cells express a T-helper 1--like phenotype after burn injury.
- Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis.
- Improved immune functions with administration of a low-fat diet in a burn animal model.
- A case for immunization against nosocomial infections
- Perioperative Recombinant Human Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Prevents Immunoinflammatory Dysfunction Associated With Major Surgery
- Fluorescent‐activated cell‐sorting analysis of intracellular interferon‐γ and interleukin‐4 in fresh and frozen human peripheral blood T‐helper cells
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