Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.
Explore this paper's citation graph
Summary
It is becoming clear that agonist-induced hydrolysis of other membrane phospholipids, particularly choline phospholipsids, by phospholIPase D and phospholiptase A2 may also take part in cell signaling.
- Type
- review
- Published
- 1992-10-23
- Cited by
- 4,451
- References
- 180
- OpenAlex
- https://openalex.org/W2086524338
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29242672
Keywords
Diacylglycerol kinase, Phospholipase, Phospholipase C, Intracellular, Protein kinase C
References
- Isolation of human eosinophil phospholipase D.
- Studies on the acyl-chain selectivity of cellular phospholipases A2.
- Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol.
- Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol.
- Mass measurement of inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol in bombesin-stimulated Swiss 3T3 mouse fibroblasts.
- Multiphasic generation of diacylglycerol in thrombin-activated human platelets.
- Molecular species analysis of a product of phospholipase D activation. Phosphatidylethanol is formed from phosphatidylcholine in phorbol ester- and bradykinin-stimulated PC12 cells.
- The regulation and cellular functions of phosphatidylcholine hydrolysis.
- Stimulation of phosphatidylcholine hydrolysis, diacylglycerol release, and arachidonic acid production by oncogenic ras is a consequence of protein kinase C activation.
- Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.
- A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.
- Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression.
- Involvement of protein kinase C in platelet-activating factor-stimulated diacylglycerol accumulation in murine peritoneal macrophages.
- Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.
- Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.
- Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. I. Inhibition of de novo phosphatidylserine biosynthesis by exogenous phosphatidylserine and its efficient incorporation.
- Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.
- Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate.
- Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation.
- Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.
Cited by
- Vascular Stem Cells in Diabetic Complications
- Extraction, separation, and analysis of plant phosphoinositides and complex glycolipids.
- Ischemic preconditioning translocates PKC-δ and -ε, which mediate functional protection in isolated rat heart.
- Protein Kinase C-delta in dopaminergic system and experimental models of Parkinson's disease
- Regulation of mammalian cell membrane biosynthesis.
- Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.
- Induction of cyclooxygenase-2 in human umbilical vein endothelial cells by lysophosphatidylcholine.
- Role of protein kinase C in the regulation of gap junctional communication.
- Protein kinase C isoforms in muscle cells and their regulation by phorbol ester and calpain.
- Role for Ceramide in Cell Cycle Arrest (*)
- Activation of protein kinase C inhibits ATP‐induced [Ca2+]i elevation in rat osteoblastic cells: Selective effects on P2Y and P2U signaling pathways
- Interleukin 4 receptor signaling in human monocytes and U937 cells involves the activation of a phosphatidylcholine-specific phospholipase C: a comparison with chemotactic peptide, FMLP, phospholipase D, and sphingomyelinase
- Expression of the annexin VIII gene in acute promyelocytic leukemia.
- Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes
- Immunochemical characterization and cellular distribution of protein kinase C isozymes in the bovine corpus luteum.
- Desensitization of cell signalling mediated by phosphoinositidase C.
- Coupling Among Energy Failure, Loss of Ion Homeostasis, and Phospholipase A2 and C Activation During Ischemia
- Structural and thermotropic properties of calcium-dimyristoylphosphatidic acid complexes at acidic and neutral pH conditions.
- Adenosine evokes potassium currents by protein kinase C activated via a novel signaling pathway in superior colliculus neurons
- The presence of phorbol ester responsive and non-responsive forms of the zeta isozyme of protein kinase C in mouse epidermal cells.
Related papers
- The simultaneous production of phosphatidic acid and diacylglycerol is essential for the translocation of protein kinase Cepsilon to the plasma membrane in RBL-2H3 cells.
- Phospholipase D in cell signalling and its relationship to phospholipase C.
- Interleukin‐2 stimulates a late increase in phosphatidic acid production in the absence of phospholipase D activation
- Phospholipase D.
- ARE CELLS RESCUED FROM ‘LOW DENSITY DEATH’ BY CO‐OPERATION BETWEEN PHOSPHOLIPASES C AND D?
- Measurement of phospholipase D activity.
- Phospholipase D and immune receptor signalling.
- A Phospholipase D-mediated Pathway for Generating Diacylglycerol in Nuclei from Madin-Darby Canine Kidney Cells (*)
- Involvement of PL-D in the alternate signal tranduction pathway of macrophages induced by an exernal stimulus