Involvement of protein kinase C in platelet-activating factor-stimulated diacylglycerol accumulation in murine peritoneal macrophages.
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Summary
The results suggest that PAF stimulates the accumulation of DAG from source other than phosphatidylinositol metabolism in peritoneal macrophages and that this occurs subsequent to the activation of protein kinase C.
- Type
- article
- Published
- 1989-06-05
- Cited by
- 45
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1489831960
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25059019
Keywords
Diacylglycerol kinase, Protein kinase C, Cell biology, Protein kinase A, Platelet
References
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Cited by
- Molecular Mechanisms of Cellular Growth
- Platelet‐activating factor receptor and signal transduction mechanisms 1
- Phosphatidylcholine breakdown and signal transduction.
- Platelet‐activating factor stimulates phosphatidic acid formation in cultured rat mesangial cells: Roles of phospholipase D, diglyceride kinase, and de novo phospholipid synthesis
- PAF effects on transmembrane signaling pathways in rat kupffer cells
- Activation of phospholipase D in normodense human eosinophils.
- Calcium Ion Impedes Translation Initiation at the Synapse
- Colony stimulating factor‐1 stimulates diacylglycerol generation in murine bone marrow‐derived macrophages, but not in resident peritoneal macrophages
- Cell signalling through phospholipid breakdown
- Enhancement of phospholipase A2 activation by phosphatidic acid endogenously formed through phospholipase D action in rat peritoneal mast cell
- Formation of diacylglycerol, inositol phosphates, arachidonic acid and its metabolites in macrophages.
- Platelet activating factor-induced increase in cytosolic calcium and transmembrane current in human macrophages
- Studies on the mechanism of uptake of low density lipoprotein-proteoglycan complex in macrophages.
- Sequential degradation of choline phosphoglycerides by phospholipase D and phosphatidate phosphohydrolase in dibutyryl cAMP-differentiated U937 cells.
- Regulation of diacylglycerol levels in carbachol-stimulated pancreatic acinar cells: relationship to the breakdown of phosphatidylcholine and metabolism to phosphatidic acid.
- Inhibition by the PAF antagonist WEB 2086 of PAF induced inositol-1,4,5-trisphosphate production in human platelets
- Phospholipase-D activation can be negatively regulated through the action of protein kinase C.
- Phospholipase D and exocytosis of the ram sperm acrosome.
- Protein kinase-C activation is required for oxytocin-induced prostaglandin production in human amnion cells.
- Platelet-activating factor mediates phosphatidylcholine hydrolysis by phospholipase D in human endometrium.
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