Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*
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Summary
The MEK affinity of U0126, its selectivity for MEK over other kinases, and its cellular efficacy suggest that this compound will serve as a powerful tool for in vitro and cellular investigations of mitogen-activated protein kinase-mediated signal transduction.
- Type
- article
- Published
- 1998-07-17
- Cited by
- 3,230
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2086262311
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9896161
Keywords
MEK inhibitor, MAPK/ERK pathway, Protein kinase A, Mitogen-activated protein kinase kinase, Kinase
References
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- The mitogen-activated protein kinase signal transduction pathway.
- Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion.
- Identification of negative and positive regulatory elements in the human renin gene.
- The steroid receptor superfamily: mechanisms of diversity
- Glucocorticoid receptor-dependent inhibition of cellular proliferation in dexamethasone-resistant and hypersensitive rat hepatoma cell variants.
- RAR‐specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage‐independent cell proliferation.
- The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors.
- Basic methods in molecular biology
- Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.
- Dissociation of p44 and p42 Mitogen-activated Protein Kinase Activation from Receptor-induced Hypertrophy in Neonatal Rat Ventricular Myocytes (*)
- A synthetic inhibitor of the mitogen-activated protein kinase cascade.
- Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.
- Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability.
- Signal transduction from multiple Ras effectors.
- Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways (*)
- Transformation of mammalian cells by constitutively active MAP kinase kinase.
Cited by
- Erk pathway inhibitor U0126 induces gamma-globin expression in erythroid cells.
- Distinct neurite outgrowth signaling pathways converge on ERK activation.
- MAP kinase, a universal suppressor of sperm centrosomes during meiosis?
- G protein–coupled receptor signaling in human ductal pancreatic cancer cells: Neurotensin responsiveness and mitogenic stimulation †
- Specificity, diversity, and convergence in VEGF and TNF‐α signaling events leading to tissue factor up regulation via EGR‐1 in endothelial cells
- Role of the ERK Pathway in the Activation of Store-mediated Calcium Entry in Human Platelets*
- The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors.
- Role of Mitogen-Activated Protein Kinase-Mediated Cytosolic Phospholipase A2 Activation in Arachidonic Acid Metabolism in Human Eosinophils1
- Kainate receptor‐mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen‐activated protein and cyclin‐dependent kinase inhibitors
- MEK inhibitor U0126 interferes with immunofluorescence analysis of apoptotic cell death.
- U0126 and PD98059, Specific Inhibitors of MEK, Accelerate Differentiation of RAW264.7 Cells into Osteoclast-like Cells*
- Oncogenic Ras Leads to Rho Activation by Activating the Mitogen-activated Protein Kinase Pathway and Decreasing Rho-GTPase-activating Protein Activity*
- Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation
- Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK.
- Growth Hormone-induced Phosphorylation of Epidermal Growth Factor (EGF) Receptor in 3T3-F442A Cells
- Elucidation of Molecular Events Leading to Neutrophil Apoptosis following Phagocytosis
- Involvement of the extracellular signal regulated kinase pathway in hydrocarbon-induced reactive oxygen species formation in human neutrophil granulocytes.
- 12-O-Tetradecanoylphorbol-13-acetate May Both Potentiate and Decrease the Generation of Apoptosis by the Antileukemic Agent Arsenic Trioxide in Human Promonocytic Cells
- Light‐ and clock‐dependent regulation of ribosomal S6 kinase activity in the suprachiasmatic nucleus
- Evidence for ERK1/2 phosphorylation controlling contact inhibition of proliferation in Madin-Darby canine kidney epithelial cells.
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