Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*

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Summary

The MEK affinity of U0126, its selectivity for MEK over other kinases, and its cellular efficacy suggest that this compound will serve as a powerful tool for in vitro and cellular investigations of mitogen-activated protein kinase-mediated signal transduction.

Type
article
Published
1998-07-17
Cited by
3,230
References
46
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Open access

Keywords

MEK inhibitor, MAPK/ERK pathway, Protein kinase A, Mitogen-activated protein kinase kinase, Kinase

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