Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links
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Summary
Accumulation of specific lipid metabolites (diacylglycerols and/or ceramides) in liver and skeletal muscle, may be a common pathway leading to impaired insulin signaling and insulin resistance.
- Type
- review
- Published
- 2012-03-02
- Cited by
- 2,289
- References
- 199
- Access
- Open access
- OpenAlex
- https://openalex.org/W2086102771
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30569251
Keywords
Biology, Insulin resistance, Resistance (ecology), Insulin, Computational biology
References
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- Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
- Prolonged fasting induces peripheral insulin resistance, which is not ameliorated by high-dose salicylate.
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- Targeting xenobiotic receptors PXR and CAR for metabolic diseases
- Insulin resistance in chronic kidney disease: new lessons from experimental models.
- Decoding Insulin Resistance and Metabolic Syndrome for Promising Therapeutic Intervention
- The effects of equal caloric high fat and western diet on metabolic syndrome, oxidative stress and vascular endothelial function in mice
- A missing link in bodyweight homeostasis: The catabolic signal of the overfed state
- Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
- Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells.
- Plasma Levels of Matrix Metalloproteinase (MMP)-2, MMP-9 and Tumor Necrosis Factor-α in Chronic Hepatitis C Virus Patients
- Importance of Hepatocyte Nuclear Factor 4α in Glycerol-induced Glucose-6-phosphatase Expression in Liver.
- Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice
- Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes.
- Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice
- Treatment of Diabetic Mice with a Combination of Ketogenic Diet and Aerobic Exercise via Modulations of PPARs Gene Programs
- Mouse models of peripheral metabolic disease.
- Protein translation associated to PERK arm is a new target for regulation of metainflammation: A connection with hepatocyte cholesterol
- Stem-cell based organ-on-a-chip models for diabetes research.
- Depletion of B cell-activating factor attenuates hepatic fat accumulation in a murine model of nonalcoholic fatty liver disease
- Mechanisms of disease: Mitochondrial dysfunction in sensory neuropathy and other complications in diabetes.
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