A PGC1α-dependent myokine that drives browning of white fat and thermogenesis
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Summary
It is shown in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin, which results in improvements in obesity and glucose homeostasis.
- Type
- article
- Published
- 2012-01-11
- Cited by
- 3,691
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W2085397620
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205227562
Keywords
FNDC5, Myokine, Endocrinology, Internal medicine, Thermogenesis
References
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- Locating proteins in the cell using TargetP, SignalP and related tools
- Physical activity and resting metabolic rate
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Cited by
- La redécouverte des adipocytes de type brun chez l’homme : un espoir pour la lutte contre les maladies métaboliques ?
- The therapeutic potential of brown adipose tissue.
- Eicosanoids in Metabolic Syndrome
- Metabolic disease: Exercise hormone fights metabolic disease
- On the relevance of brown adipose tissue in children
- Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle.
- Muscle–bone interactions: basic and clinical aspects
- A randomized clinical trial to assess the influence of a three months training program (Gym-based individualized vs. Calisthenics-based non-invidualized) in COPD-patients
- Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure
- Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle
- Molecular pathways regulating the formation of brown‐like adipocytes in white adipose tissue
- Glutathione Decrement Drives Thermogenic Program In Adipose Cells
- Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning
- Acute cold and exercise training up-regulate similar aspects of fatty acid transport and catabolism in house sparrows (Passer domesticus)
- Activating brown adipose tissue through exercise (ACTIBATE) in young adults: Rationale, design and methodology.
- Skeletal muscle as a gene regulatory endocrine organ
- Leptin administration in physiological or pharmacological doses does not alter circulating irisin levels in humans
- Role of sex steroids in β-cell function, growth and survival
- Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group.
- Energy metabolism and whole-exome sequencing-based analysis of Sasang constitution: a pilot study
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- [The cardiovascular protection of irisin and its research progress in sports field].
- Irisin as a muscle-derived hormone stimulating thermogenesis--a critical update.