Multiple roles of PPARα in brown adipose tissue under constitutive and cold conditions
Explore this paper's citation graph
Summary
This study proposes novel and multiple roles of PPARα in BAT, showing that numerous PPARβ/γ target molecules are induced on cold exposure, and that fatty acid degradation ability in wild‐type mice is markedly enhanced and also increases to same degree in PPAR α‐null mice on cold Exposure.
- Type
- article
- Published
- 2010-02-01
- Cited by
- 21
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967008795
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23102361
Keywords
Biology, Peroxisome, Peroxisome proliferator-activated receptor, Receptor, Adipose tissue
References
- Fibrates and statins rapidly and synergistically induce pyruvate dehydrogenase kinase 4 mRNA in the liver and muscles of mice.
- An NADH-linked spectrophotometric assay for pyruvate dehydrogenase complex in crude tissue homogenates.
- Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
- High resolution two-dimensional electrophoresis of proteins.
- PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.
- Identification and Importance of Brown Adipose Tissue in Adult Humans
- Role of changes in cardiac metabolism in development of diabetic cardiomyopathy.
- Peroxisome Proliferator-Activated Receptor Alpha Target Genes
- Specific elevation of transcript levels of particular protein subtypes induced in brown adipose tissue by cold exposure.
- Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue.
- The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes
- Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.
- A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
- Peroxisome proliferator-activated receptors: nuclear control of metabolism.
- NUBIScan, an in silico approach for prediction of nuclear receptor response elements.
- Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators*
- Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice.
- Rat Peroxisome Proliferator-activated Receptors and Brown Adipose Tissue Function during Cold Acclimatization*
- A Role for Estrogen-related Receptor α in the Control of Mitochondrial Fatty Acid β-Oxidation during Brown Adipocyte Differentiation*
- Peroxisome proliferator‐activated receptor α protects against alcohol‐induced liver damage
Cited by
- β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-oxidation and is Inversely Correlated with Cardiometabolic Risk Factors
- Differential expression of adipose tissue proteins between obesity‐susceptible and ‐resistant rats fed a high‐fat diet
- Adaptive expression of uncoupling protein 1 in the carp liver and kidney in response to changes in ambient temperature.
- Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice.
- Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat
- Inorganic Nitrate Promotes the Browning of White Adipose Tissue through the Nitrate-Nitrite-Nitric Oxide Pathway
- Mice fed fish oil diet and upregulation of brown adipose tissue thermogenic markers
- A PGC1α-dependent myokine that drives browning of white fat and thermogenesis
- Dietary-resistant starch improves maternal glycemic control in Goto–Kakizaki rat
- Enhanced pan‐peroxisome proliferator‐activated receptor gene and protein expression in adipose tissue of diet‐induced obese mice treated with telmisartan
- Prenatal Polycyclic Aromatic Hydrocarbon, Adiposity, Peroxisome Proliferator-Activated Receptor (PPAR) γ Methylation in Offspring, Grand-Offspring Mice
- White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways
- Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice.
- Metabolically distinct weight loss by 10,12 CLA and caloric restriction highlight the importance of subcutaneous white adipose tissue for glucose homeostasis in mice
- Effects of Butter and Phytanic acid intake on metabolic parameters and T-cell polarization
- Seasonal variations of adipose tissue in Tupaia belangeri (Mammalia: Scandentia: Tupaiidae)
- What if? Mouse proteomics after gene inactivation.
- PPAR-α activation counters brown adipose tissue whitening: a comparative study between high-fat- and high-fructose-fed mice.
- PPARs-Orchestrated Metabolic Homeostasis in the Adipose Tissue
- Photoperiod-Dependent Effects of Grape-Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats.
Related papers
- Fatty acid synthesis in mouse brown adipose tissue. The influence of environmental temperature on the proportion of whole-body fatty acid synthesis in brown adipose tissue and the liver.
- Dramatic enhancement of the specific expression of the heart‐type fatty acid binding protein in rat brown adipose tissue by cold exposure
- Heart-type Fatty Acid-binding Protein Is Essential for Efficient Brown Adipose Tissue Fatty Acid Oxidation and Cold Tolerance*
- Effects of 2[5(4-chlorphenyl)pentyl]oxirane-2-carboxylate on fatty acid synthesis and fatty acid oxidation in isolated rat hepatocytes.
- Developmental changes in fatty acid synthesis in interscapular brown adipose tissue of lean and genetically obese (ob/ob) mice.
- Liver fatty acid‐binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPAR‐α in fasting mice
- Physiologically based toxicokinetic models for prediction of complex metabolic interactions between chemical in mixtures