The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides.
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Summary
Pravastatin has pleiotropic effects on islets through membrane transport under high fat/glucose conditions, and when fat-loaded db/db mice were treated with pravastsatin, glucose intolerance and insulin resistance were prevented.
- Type
- article
- Published
- 2010-01-01
- Cited by
- 21
- References
- 35
- OpenAlex
- https://openalex.org/W2084771727
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19374968
Keywords
Pravastatin, Glucose transporter, Internal medicine, Endocrinology, Chemistry
References
- Pravastatin, an HMG-CoA Reductase Inhibitor, Is Transported by Rat Organic Anion Transporting Polypeptide, oatp2
- Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver.
- Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)
- Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications
- Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin-dependent diabetes
- β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
- Cholesterol in islet dysfunction and type 2 diabetes.
- Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types.
- Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells.
- Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association.
- The pleiotropic effects of statins
- A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)
- Effect of pravastatin on the development of diabetes and adiponectin production.
- Pravastatin and the Development of Diabetes Mellitus: Evidence for a Protective Treatment Effect in the West of Scotland Coronary Prevention Study
- Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
- Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study.
- Expression cloning of a rat liver Na(+)-independent organic anion transporter.
- Decreased albuminuria by pravastatin in hyperlipidemic diabetics.
- Carrier-mediated uptake of pravastatin by rat hepatocytes in primary culture.
- CD38 Disruption Impairs Glucose-induced Increases in Cyclic ADP-ribose, [Ca2+] i , and Insulin Secretion*
Cited by
- [Risk of type 2 diabetes mellitus associated with statin therapy: evidence and possible mechanisms].
- Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure
- Murine models for pharmacological studies of the metabolic syndrome.
- Metabolic inflammation: Connecting obesity and insulin resistance
- Modulation of adiponectin as a potential therapeutic strategy.
- Identification of Slco1a6 as a candidate gene that broadly affects gene expression in mouse pancreatic islets
- Co‐medication of pravastatin and paroxetine—A categorical study
- Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets
- Pleiotropic effects of statins: new therapeutic targets in drug design
- Differential effects of pravastatin on the pharmacokinetics of paroxetine in normal and diabetic rats
- Diabetes Secondary to Treatment with Statins
- Characterization of OATP1B3 and OATP2B1 transporter expression in the islet of the adult human pancreas
- The Role of OATP-Mediated Statin Transport in Pancreatic Beta Cell Function
- Bioconversion of mevastatin to pravastatin by various microorganisms and its applications – A review
- Predicting liver toxicity on basis of transporter interaction profiles
- Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells
- The Role of Statins (HMG-CoA Reductase Inhibitors) on Insulin Secretion from the Islets of Langerhans: A Systematic Review
- Differential effects of OATP2B1 on statin accumulation and toxicity in a beta cell model
- Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients
- Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients
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