Signal integration by JNK and p38 MAPK pathways in cancer development
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Summary
This Review highlights the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers.
- Type
- review
- Published
- 2009-08-01
- Cited by
- 2,622
- References
- 166
- Access
- Open access
- OpenAlex
- https://openalex.org/W2084472730
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205468559
Keywords
MAPK/ERK pathway, p38 mitogen-activated protein kinases, Carcinogenesis, Kinase, Context (archaeology)
References
- Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy
- p38α MAP kinase serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
- Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase.
- The Antiapoptotic Effect of Heme Oxygenase-1 in Endothelial Cells Involves the Degradation of p38α MAPK Isoform1
- Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2
- p38 MAP kinase's emerging role as a tumor suppressor.
- p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
- Selective interaction of JNK protein kinase isoforms with transcription factors.
- Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
- The promise of retinoids to fight against cancer
- p38 MAP-kinases pathway regulation, function and role in human diseases.
- Role of mitogen-activated protein kinase kinase 4 in cancer
- p38 MAP kinase: a convergence point in cancer therapy.
- Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.
- Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.
- The pathways to tumor suppression via route p38.
- Regulation of the immune response by stress‐activated protein kinases
- Feedback control of the protein kinase TAK1 by SAPK2a/p38α
- Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence.
- From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
Cited by
- Role of the JNK pathway in human diseases.
- AP-1--The Jun proteins: Oncogenes or tumor suppressors in disguise?
- Growth Factor Stimulation Induces Cell Survival by c-Jun·ATF2-dependent Activation of Bcl-XL*
- EPO improves the proliferation and inhibits apoptosis of trophoblast and decidual stromal cells through activating STAT-5 and inactivating p38 signal in human early pregnancy.
- Ligand-Directed Functional Selectivity at the Mu Opioid Receptor Revealed by Label-Free Integrative Pharmacology On-Target
- Multiple signal pathways in obesity‐associated cancer
- Functional characteristic of PC12 cells with reduced microsomal glutathione transferase 1.
- DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells.
- Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation.
- Enhancement of cisplatin-induced apoptosis by β-elemene in resistant human ovarian cancer cells
- Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells.
- Overexpressed DNA Polymerase Iota Regulated by JNK/c-Jun Contributes to Hypermutagenesis in Bladder Cancer
- In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione.
- Functional p38 MAPK Identified by Biomarker Profiling of Pancreatic Cancer Restrains Growth through JNK Inhibition and Correlates with Improved Survival
- Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
- Marine Sponge Cribrochalina vasculum Compounds Activate Intrinsic Apoptotic Signaling and Inhibit Growth Factor Signaling Cascades in Non–Small Cell Lung Carcinoma
- ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line
- Mechanisms of acquired long QT syndrome in patients with propionic academia.
- c-Myb regulates NOX1/p38 to control survival of colorectal carcinoma cells.
- Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancer
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