Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.
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Summary
COX-2, but not COX-1, gene expression is markedly elevated in most human colorectal cancers compared with accompanying normal mucosa, and COx-2 expression seems to be increased in a subset of adenomas.
- Type
- article
- Published
- 1994-10-01
- Cited by
- 2,704
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1648593433
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23895827
Keywords
Colorectal cancer, Cyclooxygenase, Adenoma, Colorectal adenoma, Medicine
References
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- Sulindac for polyposis of the colon
- Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues
- The molecular genetics of colorectal neoplasia.
- Safe limits of drinking: patients' views
- Sulindac inhibits the rate of growth and appearance of colon tumors in the rat.
Cited by
- Regulation of cyclooxygenase gene expression by glucocorticoids in cardiomyocytes
- Mucosal prostanoid receptors and synthesis in familial adenomatous polyposis
- NSAID use and decreased risk of gastrointestinal cancers.
- Why is cyclooxygenase‐2 expressed in neuroendocrine cells of the human alimentary tract?
- Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps.
- Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells.
- Inhibition of Cyclooxygenase‐2 Expression: An Approach to Preventing Head and Neck Cancer
- High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors.
- [Gastrointestinal sparing anti-inflammatory drugs--COX-2 selective inhibitors and NO-releasing NSAIDs].
- Association of Enhanced Cyclooxygenase-2 Expression With Possible Local Immunosuppression in Human Colorectal Carcinomas
- Systemic treatment of colorectal cancer.
- Comparison of cyclo-oxygenase 2 expression in colorectal serrated adenomas to expression in tubular adenomas and hyperplastic polyps
- NSAIDS in Dermatologic Therapy: Review and Preview
- Potential role of lipid peroxidation derived DNA damage in human colon carcinogenesis: studies on exocyclic base adducts as stable oxidative stress markers.
- Increased cyclooxygenase-2 expression in large flat colorectal tumors (laterally spreading tumors)
- Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2.
- Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor.
- Enhancement by interleukin-1 beta of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats: a possible mechanism for Helicobacter pylori-associated gastric carcinogenesis.
- Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas.
- Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance?
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