Role of myosin light chain kinase and myosin light chain phosphatase in the resistance arterial myogenic response to intravascular pressure.
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Summary
The molecular basis of the smooth muscle contractile mechanism is highlighted and the regulatory pathways demonstrated to participate in the control of LC(20) phosphorylation in the myogenic response are reviewed, with a focus on the Ca(2+)-dependent and Rho-associated kinase (ROK)-mediated regulation of MLCK and MLCP, respectively.
- Type
- review
- Published
- 2011-06-15
- Cited by
- 127
- References
- 190
- OpenAlex
- https://openalex.org/W2079934771
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31212213
Keywords
Myosin light-chain kinase, Myosin, Myosin-light-chain phosphatase, Immunoglobulin light chain, Rho-associated protein kinase
References
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Cited by
- Combined subthreshold dose inhibition of myosin light chain phosphorylation and MMP‐2 activity provides cardioprotection from ischaemic/reperfusion injury in isolated rat heart
- Physiological vs. pharmacological signalling to myosin phosphorylation in airway smooth muscle
- Theoretical investigation of intra- and inter-cellular spatiotemporal calcium patterns in microcirculation
- The Role of Sodium-Calcium Exchanger in the Regulation of Endothelial Function
- α5-Integrin-mediated cellular signaling contributes to the myogenic response of cerebral resistance arteries.
- Ca2+ sensitization due to myosin light chain phosphatase inhibition and cytoskeletal reorganization in the myogenic response of skeletal muscle resistance arteries
- Differential effects of myosin light chain kinase inhibition on contractility, force development and myosin light chain 20 phosphorylation of rat cervical and thoracic duct lymphatics
- Less is more: minimal expression of myoendothelial gap junctions optimizes cell–cell communication in virtual arterioles
- Efeito dos androgénios na regulação do tónus da artéria umbilical, na hipertensão arterial da gravidez
- Altered Contractile Phenotypes of Intestinal Smooth Muscle in Mice Deficient in Myosin Phosphatase Target Subunit 1
- Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
- Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness.
- Protein kinase A regulation of T-type Ca2+ channels in rat cerebral arterial smooth muscle
- Signaling in muscle contraction.
- The Role of Actin Filament Dynamics in the Myogenic Response of Cerebral Resistance Arteries
- Arteriolar Vascular Smooth Muscle Cells: Mechanotransducers in a complex environment
- Vascular TRP channels: performing under pressure and going with the flow.
- Origins of variation in conducted vasomotor responses
- Local Control of Microvascular Perfusion
- Cytoskeletal Reorganization Evoked by Rho-associated kinase- and Protein Kinase C-catalyzed Phosphorylation of Cofilin and Heat Shock Protein 27, Respectively, Contributes to Myogenic Constriction of Rat Cerebral Arteries*
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