α5-Integrin-mediated cellular signaling contributes to the myogenic response of cerebral resistance arteries.
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Summary
It is concluded that mechanotransduction by integrin adhesions and subsequent cellular signaling play a fundamental role in the cerebral arterial myogenic response.
- Type
- article
- Published
- 2015-10-01
- Cited by
- 26
- References
- 95
- Access
- Open access
- OpenAlex
- https://openalex.org/W1162818412
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32248656
Keywords
Paxillin, Cell biology, Phosphorylation, Focal adhesion, Integrin
References
- Role of myosin phosphorylation and [Ca2+]i in myogenic reactivity and arteriolar tone.
- New Insights into Vinculin Function and Regulation
- A Role for the Tyrosine Kinase Pyk2 in Depolarization-induced Contraction of Vascular Smooth Muscle*♦
- Endothelium-dependent, flow-induced dilation of isolated coronary arterioles.
- Ca2+ sensitization due to myosin light chain phosphatase inhibition and cytoskeletal reorganization in the myogenic response of skeletal muscle resistance arteries
- Intravascular pressure augments cerebral arterial constriction by inducing voltage‐insensitive Ca2+ waves
- Deciphering actin cytoskeletal function in the contractile vascular smooth muscle cell
- Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2
- Regulation of phosphoinositide-specific phospholipase C.
- Structural basis for the autoinhibition of focal adhesion kinase.
- Agonist-induced Ca2+ Sensitization in Smooth Muscle
- Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.
- Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness.
- PKC-mediated cerebral vasoconstriction: Role of myosin light chain phosphorylation versus actin cytoskeleton reorganization.
- Src Modulates Contractile Vascular Smooth Muscle Function Via Regulation of Focal Adhesions
- PLCγ1 is essential for early events in integrin signalling required for cell motility
- The Adapter Protein CrkII Regulates Neuronal Wiskott-Aldrich Syndrome Protein, Actin Polymerization, and Tension Development during Contractile Stimulation of Smooth Muscle*
- A new trick for an old dogma: ENaC proteins as mechanotransducers in vascular smooth muscle.
- PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
- The focal adhesion protein paxillin regulates contraction in canine tracheal smooth muscle
Cited by
- Analysis of phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase by Phos-tag SDS-PAGE.
- Abnormal myosin phosphatase targeting subunit 1 phosphorylation and actin polymerization contribute to impaired myogenic regulation of cerebral arterial diameter in the type 2 diabetic Goto-Kakizaki rat
- Mechanical activation of angiotensin II type 1 receptors causes actin remodelling and myogenic responsiveness in skeletal muscle arterioles
- Contribution of AT1R mechanoactivation to the arterial myogenic response and its regulation by RGS5 protein in skeletal muscle arterioles
- ROK and Arteriolar Myogenic Tone Generation: Molecular Evidence in Health and Disease
- Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease.
- Focal adhesions are involved in simulated-microgravity-induced basilar and femoral arterial remodelling in rats.
- Smooth muscle Ca2+ sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation
- Inositol 1,4,5-Trisphosphate Receptors in Hypertension
- Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole.
- Role of age, Rho‐kinase 2 expression, and G protein‐mediated signaling in the myogenic response in mouse small mesenteric arteries
- Snake Venom Disintegrins: An Overview of their Interaction with Integrins.
- RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger
- Inhibition of neurogenic and thromboxane A2‐induced human prostate smooth muscle contraction by the integrin α2β1 inhibitor BTT‐3033 and the integrin‐linked kinase inhibitor Cpd22
- Regulation of blood flow in small arteries: mechanosensory events underlying myogenic vasoconstriction
- Myogenic Tone in Peripheral Resistance Arteries and Arterioles: The Pressure Is On!
- Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone
- Arterial Aging and Age-Associated Arterial Diseases
- Death-associated protein kinase 3 (DAPK3) regulates the myogenic reactivity of cerebral arterioles
- The ATP1A2 Mutation Associated with Hemiplegic Migraines: Case Report and Literature Review
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