Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors
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Summary
This novel approach demonstrates that CPE gene transfer can be employed for a targeted suicide gene therapy of claudin-3- and -4-overexpressing tumors, leading to the rapid and efficient tumor cell killing in vitro and in vivo.
- Type
- article
- Published
- 2011-10-06
- Cited by
- 65
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W2079801231
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34712672
Keywords
Clostridium perfringens, Suicide gene, Biology, Genetic enhancement, Cancer research
References
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- The claudin gene family: expression in normal and neoplastic tissues
- Prostate-specific expression of the diphtheria toxin A chain (DT-A): studies of inducibility and specificity of expression of prostate-specific antigen promoter-driven DT-A adenoviral-mediated gene transfer.
- Deletion analysis of the Clostridium perfringens enterotoxin
- The complex interactions between Clostridium perfringens enterotoxin and epithelial tight junctions.
- Cell-Specific Cre-Mediated Activation of the Diphtheria Toxin Gene in Pituitary Tumor Cells: Potential for Cytotoxic Gene Therapy
- Therapeutic genes for cancer gene therapy
- Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin‐3, a tight junction integral membrane protein
- Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptors
- Pyroptosis: host cell death and inflammation
- Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors
- Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin.
- Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics
- Bacteria and bacterial toxins as therapeutic agents for solid tumors.
- Identification of a Prepore Large-Complex Stage in the Mechanism of Action of Clostridium perfringens Enterotoxin
- Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
Cited by
- Claudin expression in breast cancer: high or low, what to expect?
- The potential of clostridial spores as therapeutic delivery vehicles in tumour therapy.
- Expression of claudins relates to tumour aggressivity, location and recurrence in ependymomas.
- CLAUDINA- 3 E CLAUDINA- 4, POTENCIAIS MARCADORES DE AGRESSIVIDADE NO CARCINOMA ENDOMETRIAL TIPO I
- Helicobacter pylori-Induced Alteration of Epithelial Cell Signaling and Polarity: A Possible Mechanism of Gastric Carcinoma Etiology and Disparity
- Tight Junctions in Cancer Metastasis
- Mechanism of Clostridium perfringens Enterotoxin Interaction with Claudin-3/-4 Protein Suggests Structural Modifications of the Toxin to Target Specific Claudins*
- Tumor-colonizing bacteria: A potential tumor targeting therapy
- Bacterial vectors for imaging and cancer gene therapy: a review
- Current status of gene therapy for cancer
- Claudins Overexpression in Ovarian Cancer: Potential Targets for Clostridium Perfringens Enterotoxin (CPE) Based Diagnosis and Therapy
- Claudin-4 as therapeutic target in cancer.
- A claudin 3 and claudin 4-targeted Clostridium perfringens protoxin is selectively cytotoxic to PSA-producing prostate cancer cells.
- Claudin-6: a novel receptor for CPE-mediated cytotoxicity in ovarian cancer
- Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines
- Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
- The latest advances of experimental research on targeted gene therapy for prostate cancer
- Suicide Gene Therapy for Cancer – Current Strategies
- Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer
- Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5
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