Flavonoids: antioxidants or signalling molecules?
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Summary
A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration.
- Type
- review
- Published
- 2004-04-01
- Cited by
- 1,992
- References
- 124
- OpenAlex
- https://openalex.org/W2078166953
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24924943
Keywords
Protein kinase B, Kinase, Cell biology, Protein kinase A, Signal transduction
References
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Cited by
- AVALIAÇÃO DO EFEITO FOTOPROTETOR DE TRÊS EXTRATOS DE PLANTAS DA ANTÁRTICA POR DIFERENTES MODELOS BIOLÓGICOS
- Polyphenols in cerebral ischemia
- Antioxidant activity of isocoumarins isolated from Paepalanthus bromelioides on mitochondria.
- Some characteristics of quercetin-induced cytotoxicity on rat thymocytes under in vitro condition.
- Influence of glucose on cyanidin 3-glucoside absorption in rats.
- Quality, nutritional quality and nutraceutical value as a new task for strawberry breeding
- Response of wild-type and high pigment-1 tomato fruit to UV-B depletion: flavonoid profiling and gene expression
- Naringenin, a flavanone inhibits the proliferation of cerebrally implanted C6 glioma cells in rats.
- Inhibition of rat mammary microsomal oxidation of ethanol to acetaldehyde by plant polyphenols
- Evaluation of red chicory extract as a natural antioxidant by pure lipid oxidation and yeast oxidative stress response as model systems.
- Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells
- Glabridin protects paraoxonase 1 from linoleic acid hydroperoxide inhibition via specific interaction: a fluorescence-quenching study.
- Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes.
- Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.
- The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study.
- Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective.
- Genotypic Variation in Tomatoes Affecting Processing and Antioxidant Attributes
- Inhibitory Kinetics and Mechanism of Flavonoids Extracted from Cotinus coggygria Scop. Against Glioblastoma Cancer
- Prenatal therapeutics and programming of cardiovascular function
- CHARACTERIZATION OF THE CONTENT OF ANTIOXIDANT SUBSTANCES IN THE WINES OF SARDINIA
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