Preoperative Radiation with Concurrent 5-Fluorouracil for Locally Advanced T4-Primary Rectal Cancer
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Summary
A combination of high-dose preoperative radiochemotherapy followed by extended surgery can achieve clear resection margins in more than 80% of patients with locally advanced cT4 rectal tumor.
- Type
- article
- Published
- 2000-04-01
- Cited by
- 69
- References
- 17
- OpenAlex
- https://openalex.org/W2078103786
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9161773
Keywords
Medicine, Surgery, Radiation therapy, Abdominoperineal resection, Colorectal cancer
References
- Pharmacokinetics of fluorouracil in humans.
- Effective surgical adjuvant therapy for high-risk rectal carcinoma.
- Pelvic exenteration for locally advanced rectal carcinoma: factors predicting improved survival.
- Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer.
- Extended resection of fixed rectal cancer
- Pelvic Radiation Therapy in Rectal Cancer: Technical Considerations.
- Aggressive multimodality treatment for locally advanced irresectable rectal cancer
- Adjuvant preoperative radiotherapy for locally advanced rectal carcinoma
- Preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer.
- Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5‐fluorouracil infusion and radiation therapy
- Preoperative irradiation for unresectable rectal and rectosigmoid carcinomas
- Preoperative chemotherapy and radiation therapy for locally advanced primary and recurrent rectal carcinoma. A report of surgical morbidity
- Combined preoperative radiation and mitomycin/5-fluorouracil treatment for locally advanced rectal adenocarcinoma.
- Intraoperative brachytherapy alone for incomplete resected recurrent rectal cancer.
- Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-Fluorouracil or ftorafur and X rays.
- Preoperative concurrent 5-fluorouracil infusion, mitomycin C and pelvic radiation therapy in tethered and fixed rectal carcinoma.
- Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery.
Cited by
- Kombination von Radiotherapie und Gemcitabine Bewertung der klinischen Daten auf der Basis experimenteller Erkenntnisse
- Smaller tumor size is associated with poor survival in T4b colon cancer.
- Amifostine as Radioprotective Agent for the Rectal Mucosa during Irradiation of Pelvic Tumors
- Volumetric Parameters Changes of Sequential 18F-FDG PET/CT for Early Prediction of Recurrence and Death in Patients With Locally Advanced Rectal Cancer Treated With Preoperative Chemoradiotherapy
- Neoadjuvant radiochemotherapy in rectal cancer: for which patients and tumor stages?
- Adjuvant versus Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer A Progress Report of a Phase-III Randomized Trial (Protocol CAO/ARO/AIO-94)
- New Perspectives on Predictive Biomarkers of Tumor Response and Their Clinical Application in Preoperative Chemoradiation Therapy for Rectal Cancer
- Can neoadjuvant radiochemotherapy improve the results of multivisceral resections in advanced rectal carcinoma (cT4a)
- Survival after surgical treatment of cancer of the rectum
- Perioperative radiotherapy and concurrent radiochemotherapy in rectal cancer.
- Influence of irradiation on neutrophilic granulocyte function
- Radiotherapy in rectal cancer: technical aspects and regimens
- Neoadjuvant systemic fluorouracil and mitomycin C prior to synchronous chemoradiation is an effective strategy in locally advanced rectal cancer
- Neoadjuvante Radiotherapie und Radiochemotherapie: Standards und Ausblick
- Adjuvant vs. neoadjuvant radiochemotherapy for locally advanced rectal cancer: the German trial CAO/ARO/AIO‐94
- The role of sequential 18F‐FDG PET/CT in predicting tumour response after preoperative chemoradiation for rectal cancer
- Operationsrisiko nach neoadjuvanter Therapie gastrointestinaler Karzinome
- Late small bowel toxicity after adjuvant treatment for rectal cancer
- Determining Therapeutic Approaches in the Elderly with Rectal Cancer
- Phase II study of concomitant chemoradiotherapy with local hyperthermia and metronidazole for locally advanced fixed rectal cancer
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