Adjuvant versus Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer A Progress Report of a Phase-III Randomized Trial (Protocol CAO/ARO/AIO-94)
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Summary
The patient accrual of the trial is satisfactory, neoadjuvant radiochemotherapy is well tolerated and bears no higher risk for postoperative morbidity, and primary endpoints include rate of curative (R0) resections and sphincter saving procedures, toxicity of radiochemistry, surgical complications and quality of life.
- Type
- article
- Published
- 2001-03-01
- Cited by
- 148
- References
- 34
- OpenAlex
- https://openalex.org/W1884971637
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19973582
Keywords
Medicine, Total mesorectal excision, Colorectal cancer, Surgery, Radiation therapy
References
- Survival after postoperative combination treatment of rectal cancer.
- Prognostic factors of rectum carcinoma--experience of the German Multicentre Study SGCRC. German Study Group Colo-Rectal Carcinoma.
- Long term follow up
- Rectal Cancer Surgery
- Improved survival with preoperative radiotherapy in resectable rectal cancer.
- Combined modality therapy of rectal cancer: decreased acute toxicity with the preoperative approach.
- Effective surgical adjuvant therapy for high-risk rectal carcinoma.
- Pre- or postoperative radiotherapy in rectal and rectosigmoid carcinoma. Report from a randomized multicenter trial.
- Use of preoperative ultrasound staging for treatment of rectal cancer
- Preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer.
- Clinical staging of rectal cancer.
- Conservative Surgery for Low Rectal Carcinoma After High‐Dose Radiation Functional and Oncologic Results
- Adjuvant therapy for rectal cancer--a good first step.
- Postoperative mortality in rectal cancer treated with or without preoperative radiotherapy: Causes and risk factors
- Preliminary results of preoperative 5-fluorouracil, low-dose leucovorin, and concurrent radiation therapy for clinically resectable T3 rectal cancer
- Three-dimensional endosonography for staging of rectal cancer.
- Neoadjuvant and adjuvant radio- and radio-chemotherapy of rectal carcinomas
- Preoperative Radiation with Concurrent 5-Fluorouracil for Locally Advanced T4-Primary Rectal Cancer
- Total mesorectal excision--the new golden standard of surgery for rectal cancer.
- Total mesorectal excision (TME) with or without preoperative radiotherapy in the treatment of primary rectal cancer. Prospective randomised trial with standard operative and histopathological techniques. Dutch ColoRectal Cancer Group.
Cited by
- New Aspects of Adjuvant Radiotherapy in Primarily Resectable Rectal Cancer
- Restaging of Locally Advanced Carcinoma of the Rectum with MR Imaging after Preoperative Radio-Chemotherapy plus Regional Hyperthermia
- Adjuvant therapy of resectable rectal cancer.
- Combined modality therapy for rectal cancer.
- Palliative Interstitial HDR Brachytherapy for Recurrent Rectal Cancer
- Neoadjuvant Radiochemotherapy in Locally Advanced Gastric Carcinoma
- Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients: assessment of acute toxicity and treatment compliance. Report of the 22921 randomised trial conducted by the EORTC Radiotherapy Group.
- Amifostine as Radioprotective Agent for the Rectal Mucosa during Irradiation of Pelvic Tumors
- Effects of preoperative radiochemotherapy with capecitabine for resectable locally advanced rectal cancer in elderly patients.
- The Potential Role of TGFβ1, TGFβ2 and TGFβ3 Protein Expression in Colorectal Carcinomas
- Radiochemotherapy in Combination with Regional Hyperthermia in Preirradiated Patients with Recurrent Rectal Cancer
- Präoperative Diagnostik beim lokal fortgeschrittenen Rektumkarzinom (≥T3 oder N+)
- Importance of preoperative MRI staging and histological stage for carcinomas of the mid and lower thirds of rectum in a district general hospital
- T-level downstaging and complete pathologic response after preoperative long-term radiochemotherapy for locally advanced rectal cancer.
- Novel Carcinoembryonic-Antigen-(CEA)-Specific Pretargeting System to Assess Tumor Cell Viability after Irradiation of Colorectal Cancer Cells
- Overview of the role of preoperative radiotherapy to increase sphincter preservation for rectal cancer.
- Survival Benefit with Radiation Therapy in Node-Positive Breast Carcinoma Patients
- Fibrotic Changes after Postmastectomy Radiotherapy and Reconstructive Surgery in Breast Cancer
- Firmas Génicas de respuesta al tratamiento neoadyuvante en el cáncer de recto
- Rectal cancer surgery : Defunctioning stoma, anastomotic leakage and postoperative monitoring
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