The Role of DNA Methylation in Mammalian Epigenetics
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Summary
M Mammals appear to have taken advantage of the possibilities afforded by cytosine methylation to provide a heritable mechanism for altering DNA-protein interactions to assist in such silencing of X-linked and imprinted genes.
- Type
- article
- Published
- 2001-08-10
- Cited by
- 2,060
- References
- 37
- OpenAlex
- https://openalex.org/W2078028724
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11344610
Keywords
DNA methylation, Biology, Epigenetics, Epigenetics of physical exercise, Genetics
References
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- Alterations in DNA methylation: a fundamental aspect of neoplasia.
- Cancer-epigenetics comes of age
- Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
- Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
- CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
- Epigenetic Reprogramming in Mammalian Development
- Dnmt3a binds deacetylases and is recruited by a sequence‐specific repressor to silence transcription
- CpG islands as gene markers in the human genome.
- Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity
- Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.
- Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region.
- Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid
- Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
- The establishment and maintenance of DNA methylation patterns in mouse somatic cells.
- The hypervariable DXS255 locus contains a LINE-1 repetitive element with a CpG island that is extensively methylated only on the active X chromosome.
- Cytosine methylation and the ecology of intragenomic parasites.
Cited by
- Use of SNP-arrays for ChIP assays: computational aspects.
- Chromatin structure and gene regulation in the immune system.
- Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases
- Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
- Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
- DNA methylation in the immune system.
- Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation.
- SHP-1 promoter 2 methylation in normal epithelial tissues and demethylation in psoriasis
- Mutagenesis in mice of nuclear hormone receptor binding sites in the Igf2/H19 imprinting control region
- Expression and Regulation of Heme Oxygenase Isozymes in the Developing Mouse Cortex
- Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists.
- Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer
- Epigenetics of human asthma and allergy: promises to keep.
- Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women's cancers.
- New primers for methylation-specific polymerase chain reaction enhance specificity of detecting STAT1 methylation.
- Epigenetic regulation of CXCR4 expression by the ocular microenvironment.
- Practical applications for epigenetic biomarkers in cancer diagnostics.
- DNA methylation and transcriptional noise
- Gadd45 proteins: key players of repair-mediated DNA demethylation.
- Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS
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