Recombinant human tumor necrosis factor-beta entrapped in liposomes formed by a modification of the dehydration-rehydration method retains potent cytotoxic activity on L929 cells in vitro.
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Summary
Recombinant human tumor necrosis factor-beta (rhTNF-beta) may be encapsulated with high efficiency in phosphatidylcholine and distearoylphosphatidolcholine liposomes, with entrapment values of 93.4% and 92.3%, respectively.
- Type
- article
- Published
- 1992-01-01
- Cited by
- 0
- References
- 9
- Access
- Open access
- OpenAlex
- https://openalex.org/W2077657476
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31900522
Keywords
Liposome, Cytotoxicity, Cytotoxic T cell, In vitro, Recombinant DNA
References
- Liposome-associated tumor necrosis factor retains bioactivity in the presence of neutralizing anti-tumor necrosis factor antibodies.
- Dehydration-Rehydration Vesicles: A Simple Method for High Yield Drug Entrapment in Liposomes
- Bacterial Expression, Facile Purification and Properties of Recombinant Human Lymphotoxin (Tumor Necrosis Factor Beta)
- Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
- Tumour necrosis factors in clinical practice.
- Liposomes as antigen vehicles to increase immunogenicity: effects of variation of structural characteristics.
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