A Gene Network Regulating Lysosomal Biogenesis and Function
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Summary
It is found that most lysosomal genes exhibit coordinated transcriptional behavior and are regulated by the transcription factor EB (TFEB), providing a potential therapeutic target to enhance cellular clearing in lysOSomal storage disorders and neurodegenerative diseases.
- Type
- article
- Published
- 2009-07-24
- Cited by
- 2,393
- References
- 23
- OpenAlex
- https://openalex.org/W2077499130
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20353685
Keywords
Biogenesis, Function (biology), Cell biology, Gene, Organelle biogenesis
References
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- An epidemic of complex dysmorphologic syndromes in southeast Spain?
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Cited by
- LOSS OF TRPML1 ALTERS CELLULAR FUNCTIONS OUTSIDE OF THE LYSOSOME: DISSECTING THE RELATIONSHIP BETWEEN LYSOSOMAL AND MITOCHONDRIAL HEALTH IN MLIV
- Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking
- Functional Analysis of Lysosomes During Mouse Preimplantation Embryo Development
- Therapeutic approaches for lysosomal storage diseases: a patent update.
- Differential autophagic responses to nano-sized materials.
- Targeting α‐synuclein: Therapeutic options
- The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity
- Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
- Retinal Degeneration in Mice Deficient in the Lysosomal Membrane Protein CLN7.
- Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases
- Lysosomal Biology in Cancer
- Transcriptional factor EB regulates macrophage polarization in the tumor microenvironment
- Silver nanoparticles induce lysosomal-autophagic defects and decreased expression of transcription factor EB in A549 human lung adenocarcinoma cells.
- Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging
- Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα
- Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
- Determination of the autophagic flux in murine and human peripheral blood mononuclear cells
- Effects of Trans Fats in Human Macrophages
- Autophagy and Cell Autonomous Neurodegeneration in Niemann-Pick type C Disease
- Effet de la composition en macronutriments de l’aliment sur les mécanismes de contrôle de l’autophagie chez la truite arc-enciel (Oncorhynchus mykiss)
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