Reconstituting Organ-Level Lung Functions on a Chip
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Summary
Mechanically active “organ-on-a-chip” microdevices that reconstitute tissue-tissue interfaces critical to organ function may expand the capabilities of cell culture models and provide low-cost alternatives to animal and clinical studies for drug screening and toxicology applications.
- Type
- article
- Published
- 2010-06-25
- Cited by
- 3,856
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W2076922024
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11011310
Keywords
Proinflammatory cytokine, Extracellular matrix, Lung, Cell biology, Organ-on-a-chip
References
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- Topographical Micropatterning of Poly(dimethylsiloxane) Using Laminar Flows of Liquids in Capillaries
- Microfluidic culture platform for neuroscience research
- Morphological response of human endothelial cells subjected to cyclic strain in vitro.
- The potential environmental impact of engineered nanomaterials
- Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide.
- Microscale culture of human liver cells for drug development
- Computer-controlled microcirculatory support system for endothelial cell culture and shearing.
- Adverse cardiovascular effects of air pollution
- In vitro analysis of a hepatic device with intrinsic microvascular-based channels
- Cells on chips
- The third dimension bridges the gap between cell culture and live tissue
- Growth of endothelial cells on microfabricated silicon nitride membranes for anin vitro model of the blood-brain barrier
- Development of an osteoblast-based 3D continuous-perfusion microfluidic system for drug screening
- Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems
- Cellular mechanotransduction: putting all the pieces together again
- Pulmonary surfactant: functions, abnormalities and therapeutic options
- A microfabricated array bioreactor for perfused 3D liver culture.
- Microfeature guided skeletal muscle tissue engineering for highly organized 3-dimensional free-standing constructs.
Cited by
- Lab on a Microchip and Microfluidic Technologies: Toxology and Drug Development
- A subcellular compartmental modeling approach to pulmonary drug development
- Effects of Extracellular Surface Interactions on Mass Transport across Epithelial Cells.
- Functional Co-substituted Poly[(amino acid ester)phosphazene] Biomaterials
- Microfluidic technologies for accelerating the clinical translation of nanoparticles
- Bridge over troubled waters: understanding the synthetic and biological identities of engineered nanomaterials.
- Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment.
- Microfluidics for nano-pathophysiology.
- Microphysiological modeling of the reproductive tract: a fertile endeavor
- Interview with Donald E Ingber.
- A coculture model of the lung–blood barrier: the role of activated phagocytic cells.
- In vitro investigation of silica nanoparticle uptake into human endothelial cells under physiological cyclic stretch
- Numerical investigation of dynamic microorgan devices as drug screening platforms. Part I: Macroscale modeling approach & validation
- A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells
- Tissue Engineering in Ophthalmology: Implications for Eyelid Reconstruction.
- WAT-on-a-chip: A physiologically relevant microfluidic system incorporating white adipose tissue
- Native extracellular matrix-derived semipermeable, optically transparent, and inexpensive membrane inserts for microfluidic cell culture
- Embedded Multimaterial Extrusion Bioprinting
- Cytostretch, an Organ-on-Chip Platform
- Mesenchymal Stem Cells as a Promising Cell Source for Integration in Novel In Vitro Models
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