Predictive value of in vitro model systems in toxicology.
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Summary
The value and use of in vitro model systems in industrial development of new pharmaceutical agents and selective examples of these model systems are provided to better understand cutaneous and ocular toxicity and the role of drug metabolism in the hepatotoxicity of selected agents are examined.
- Type
- review
- Published
- 1998-04-01
- Cited by
- 133
- References
- 98
- OpenAlex
- https://openalex.org/W2153043774
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2833079
Keywords
Toxicity, In vitro, Popularity, Drug, Pharmacology
References
- A tissue culture assay of corneal epithelial wound closure.
- Drug metabolism in adult rat hepatocytes in primary monolayer culture.
- Effect of Tissue-Culture Substratum and Extracellular Matrix Overlay on Liver-Selective and Xenobiotic Inducible Gene Expression in Primary Rat Hepatocytes.
- In vitro methods in pharmaceutical research
- Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes.
- Preparation of isolated rat liver cells.
- Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction.
- Use of human hepatocytes to study P450 gene induction.
- Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response.
- Multi‐faceted regulation of cell differentiation by extracellular matrix
- Early Cytokine Synthesis in the Excised Mouse Cornea
- In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture system.
- Soaps and Detergents: Alternatives to Animal Eye Irritation Tests
- Interleukin-1 production after treatment with non-ionic surfactants in a murine keratinocytes cell line.
- Maintenance of microsomal cytochromes b5 and P-450 in primary cultures of parenchymal liver cells on collagen membranes.
- Keratinocyte-derived proinflammatory key mediators and cell viability as in vitro parameters of irritancy: a possible alternative to the Draize skin irritation test.
- Delayed Toxicity of Benzalkonium Chloride and Sodium Dodecyl Sulfate Evaluated in Primary Cultures of Rabbit Corneal Epithelial Cells
- Long-term maintenance and induction of cytochrome P-450 in primary cultures of rat hepatocytes.
- Corneal epithelial wound closure in tissue culture: an in vitro model of ocular irritancy.
- The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland.
Cited by
- An examination of whether human placental perfusion allows accurate prediction of placental drug transport: studies with diazepam.
- Development of a Cell-Based Biosensor for Compound Detection
- In vitro toxicity screening of chemical mixtures using HepG2/C3A cells.
- Proliferation and LDH leakage in cell cultures of animal and insect origin exposed to insecticide endosulfan.
- Erythrocyte Toxicities of Imidazolidinyl Urea and Diazolidinyl Urea
- The use of genomics in model in vitro systems.
- Carbon monoxide-releasing molecules (CO-RMs) : effects on physiology and ischaemia-reperfusion injury in the kidney
- Integration of an in vitro blood brain barrier model with organic electrochemical transistors
- Cytotoxicity of Resorcinol Under Short- and Long-Term Exposure in Vitro
- Evaluation of the Primary Mouse Hepatocyte Model for the Prediction of Genotoxicity
- Development of a high throughput 3D perfused liver tissue bioreactor
- Prediction of hepatotoxic responses in humans: A toxicogenomics-based parallelogram approach
- A real-time in vitro assay as a potential predictor of in vivo tumor imaging properties.
- Entwicklung eines Hepatozytenbioreaktors zur Anwendung in der Toxikologie und Metabolismusforschung: Ein neuartiges in vitro Modell für die online Testung von hepatoaktivierten Substanzen an Indikatorzellen
- Cytoprotection of methionine on hyperthermia‐induced damage in bovine mammary epithelial cells
- Assessment of research models for testing gene-environment interactions.
- Methionine protects against hyperthermia-induced cell injury in cultured bovine mammary epithelial cells
- In vitro and in vivo studies of natural products: A challenge for their valuation. The case study of chamomile (Matricaria recutita L.)
- Identification of molecular signatures predicting the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs).
- Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure.
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