Neutral endopeptidase modulation of septic shock
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Summary
Targeted disruption of the NEP locus in mice results in enhanced lethality to endotoxin shock with a pronounced gene dosage effect, and this unexpected finding indicates an important protective role for NEP in septic shock.
- Type
- article
- Published
- 1995-06-01
- Cited by
- 168
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1999319209
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28034403
Keywords
Neprilysin, Enkephalinase, Septic shock, Acetylcholinesterase, Metalloproteinase
References
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- The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).
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- Characterization of murine CD10, an endopeptidase expressed on bone marrow adherent cells.
- Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung.
- CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides.
- Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing
- ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1.
- Four different interleukin-1 species sensitize to the lethal action of tumour necrosis factor.
- High-affinity enkephalin-degrading peptidase in brain is increased after morphine
- A monoclonal antibody to human acute lymphoblastic leukaemia antigen
- Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor.
- The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice
- Candidate leukaemia-specific antigen in man
- Inactivation of atrial natriuretic factor in mice in vivo: crucial role of enkephalinase (EC 3.4.24.11).
- Regulation of neurogenic inflammation by neutral endopeptidase.
- Role of peptidases in bradykinin-induced increase in vascular permeability in vivo.
- Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
Cited by
- Genetically altered animal models in the kallikrein-kinin system
- Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.
- Cell-Surface Peptidases
- Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications
- Soluble Recombinant Neutral Endopeptidase (CD10) as a Potential Antiinflammatory Agent
- The localization of c-Abl in Alzheimer's disease
- Neprilysin Deficiency Alters the Neuropathological and Behavioral Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease
- Modulation of Cutaneous Inflammation by Angiotensin-Converting Enzyme1
- Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
- Wirkung einer Vasopeptidase-Hemmung auf die linksventrikuläre Hypertrophie und Funktion am Modell der 5/6-nephrektomierten Ratte
- Natriuretic Peptide Metabolism, Clearance and Degradation
- Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX
- Accumulation of murine amyloid-β mimics early Alzheimer's disease.
- Neutral Endopeptidase Inhibition Enhances Substance P Mediated Inflammation Due to Hypomagnesemia
- Neprilysin, obesity and the metabolic syndrome
- Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function*
- Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit.
- Neutral endopeptidase is expressed on the follicular granulosa cells of rabbit ovaries.
- A Familial Mutation Renders Atrial Natriuretic Peptide Resistant to Proteolytic Degradation*
- Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies.
Related papers
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