Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

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Summary

It is demonstrated that half of the myofibroblasts escape apoptosis during regression of liver fibrosis, down-regulate fibrogenic genes, and acquire a phenotype similar to, but distinct from, quiescent HSCs in their ability to more rapidly reactivate into my ofibro Blasts in response to fibrogened stimuli.

Type
article
Published
2012-05-07
Cited by
777
References
29
Access
Open access

Keywords

Myofibroblast, Hepatic stellate cell, Fibrosis, Phenotype, Pathology

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