Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
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Summary
It is demonstrated that half of the myofibroblasts escape apoptosis during regression of liver fibrosis, down-regulate fibrogenic genes, and acquire a phenotype similar to, but distinct from, quiescent HSCs in their ability to more rapidly reactivate into my ofibro Blasts in response to fibrogened stimuli.
- Type
- article
- Published
- 2012-05-07
- Cited by
- 777
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W2075290880
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22546223
Keywords
Myofibroblast, Hepatic stellate cell, Fibrosis, Phenotype, Pathology
References
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- Cotransplanted hepatic stellate cells enhance vascularization of islet allografts
- The role of matrix stiffness in regulating cell behavior
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- 5′ Stem-Loop of Collagen α1(I) mRNA Inhibits Translationin Vitro but Is Required for Triple Helical Collagen Synthesis in Vivo*
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- Hsp72-Mediated Suppression of c-Jun N-Terminal Kinase Is Implicated in Development of Tolerance to Caspase-Independent Cell Death
Cited by
- Review article: the prevention and reversal of hepatic fibrosis in autoimmune hepatitis
- Functional Immune Anatomy of the Liver—As an Allograft
- Liver Fibrosis: From Pathogenesis to Novel Therapies
- Epigenetic regulation of hepatic stellate cell activation and liver fibrosis
- Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms.
- Targeting Endothelial Erk1/2-Akt Axis as a Regeneration Strategy to Bypass Fibrosis during Chronic Liver Injury in Mice.
- Reversibility of liver fibrosis.
- Optimising stem cell therapy for liver disease through modulation of sphingosine 1-phosphate signalling
- Reversibility and heritability of liver fibrosis: Implications for research and therapy.
- Origin and Function of Myofibroblasts in the Liver
- Reversibility of Liver Fibrosis
- Regulation of hepatic stellate cell phenotype and cytoglobin expression by extracellular matrix proteins
- Hepatic Progenitor Cells in Action: Liver Regeneration or Fibrosis?
- Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1
- Linking Immune Responses with Fibrosis in Allergic Eye Disease
- Liver cell types derived from pluripotent stem cells
- Biomarkers of liver fibrosis detecting with electrochemical immunosensor on clinical serum
- Cre-ativity in the liver: Transgenic approaches to targeting hepatic nonparenchymal cells
- Strategies and Endpoints of Antifibrotic Drug Trials
- Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo
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