Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
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Summary
It is suggested that apoptosis of activated HSC may vitally contribute to resolution of fibrosis by acting as a mechanism for removing the cell population responsible for both producing fibrotic neomatrix and protecting this matrix from degradation via their production of TIMPs.
- Type
- article
- Published
- 1998-08-01
- Cited by
- 1,091
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W9691091
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2300806
Keywords
Bottle, History, Archaeology
References
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- Alteration in expression of MMP-1 and MMP-2 but not TIMP-1 and TIMP-2 in hereditary gingival fibromatosis is mediated by TGF-beta 1 autocrine stimulation.
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