A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.

Keywords

hERG, Long QT syndrome, Biology, Missense mutation, Genetics

References

• The 1993–94 Généthon human genetic linkage mapGàbor Gyapay, Jean Morissette, Alain Vignal — 1994
• Functional expression of a rat homologue of the voltage gated either á go‐go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart.Jost Ludwig, Heinrich Terlau, Frank Wunder — 1994
• Cardiac Electrophysiology: From Cell to BedsideD. Zipes, J. Jalife — 1990
• Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.G.M. Lathrop, J.-M. Lalouel, Cécile Julier — 1985
• Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes.Charles Antzelevitch, Serge Sicouri — 1994
• Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early afterdepolarizations?Borys Surawicz — 1989
• CONGENITAL CARDIAC ARRHYTHMIA.Carmela Romano — 1965
• Shaker, Shal, Shab, and Shaw express independent K+ current systems.Manuel Covarrubias, Aguan Wei, Lawrence Salkoff — 1991
• Identification of a family of muscarinic acetylcholine receptor genes.Tom I. Bonner, Noel J. Buckley, Alice C. Young — 1987
• Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene.Mark Keating, Donald L. Atkinson, Christine Dunn — 1991
• The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome.G. Michael Vincent, Katherine W. Timothy, Mark Leppert — 1992
• The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis.Michael A. Curran — 1993
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.Andrew P. Feinberg, Bert Vogelstein — 1983
• Locus heterogeneity of autosomal dominant long QT syndrome.Michael A. Curran, Donald L. Atkinson, K Timothy — 1993
• Early Afterdepolarizations: Mechanism of Induction and Block A Role for L‐Type Ca2+ CurrentCraig T. January, Janet Riddle — 1989
• Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products.Douglas A. Marchuk, Mitchell L. Drumm, Ann M. Saulino — 1991
• The long QT syndrome.Peter J. Schwartz — 1997
• Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneityChangan Jiang, Donald L. Atkinson, Jeffrey A. Towbin — 1994
• Linkage Analysis and Long QT Syndrome: Using Genetics to Study Cardiovascular DiseaseMark Keating — 1992
• Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa — 1989

Cited by

• Stereoselective interactions between local anesthetics and ion channels.Carmen Valenzuela, Cristina Moreno, Alicia de la Cruz — 2012
• On the trail of genetic culprits in Williams syndrome.Ken Saul — 1997
• Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel.González Ruíz, José Enríque — 1998
• Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease.勉 山野辺, 徳紀 松嶋, 勝 難波 — 1998
• Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit.Damien Clauzel, Joona Laukkanen, Claudia Roda — 1998
• Screening for copy number variation in genes associated with the long QT syndrome: clinical relevance.Julien Barc, François Briec, Sébastien Schmitt — 2011
• Homozygous premature truncation of the HERG protein : the human HERG knockout.Shojaeyan Ali — 1999
• Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM Kinase II由起 二ツ森 — 1999
• A plethora of mechanisms in the HERG-related long QT syndrome. Genetics meets electrophysiology.Mary Lyon, Scott Bergeson — 1999
• Channelopathies can cause epilepsy in manTomas Roslin — 2002
• A Simple Method for Evaluating Abnormal Lengthening of the QT Interval During the Face Immersion TestНаталья Анатольевна Дривольская — 2002
• Defective Human Ether-à-go-go-related Gene Trafficking Linked to an Endoplasmic Reticulum Retention Signal in the C Terminus*Jozef Pócs — 2002
• Genotyping of Drug TargetsFrancisco Checa y Olmos, Concepción Fernández Soto — 2002
• Bertosamil blocks HERG potassium channels in their open and inactivated statesRodríguez Robledo, María de Loreto — 2002
• Physiology of EAG K+ ChannelsChristiane K. Bauer, Jürgen R. Schwarz — 2001
• Psychotropic Drugs, Cardiac Arrhythmia, and Sudden DeathCedric Tolliver — 2003
• Expression and function of KCNH2 (HERG) in the human jejunum.R. Żbikowski, Anna Lebiedzińska, J. Czaja — 2003
• ERG K+ currents regulate pacemaker activity in ICC.J. Kastner — 2003
• Molecular Genetics of Arrhythmias and Cardiovascular Conditions Associated with ArrhythmiasCharles Antzelevitch — 2003
• Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with Type 1 diabetesEmilie Eriksson, Sofia Wigert — 2004

Related papers

• Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig modelXiaozhou Yao, D. L. Anderson, Sean Ross — 2008
• In Vivo Effects of the IKr Agonist NS3623 on Cardiac Electrophysiology of the Guinea PigRie Schultz Hansen, Søren‐Peter Olesen, Lars Christian B. Rønn — 2008
• An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related DataChristopher E. Pollard, Matthew Skinner, Stanley E. Lazic — 2017
• Abstract 14372: The Acquired Long QT-Causing Drugs Haloperidol and Terfenadine Cause Defects in HERG TraffickingAbagail McKernan, Haider Mehdi, Alexander Greiner — 2021
• How to fluorescently label the potassium channel: A case in hERG.Xiaomeng Zhang, Beilei Wang, Zhenzhen Liu — 2020
• HERG trafficking and pharmacological rescue of LQTS-2 mutant channels.Gail A. Robertson, Craig T. January — 2006
• Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.Colleen E. Clancy — 2001
• Advances in Study of LQT2 Syndrome-Related HERG GeneLou Jian-shi — 2007
• hERG channel function: beyond long QTJoseph J. Babcock, Man Li — 2013