hERG channel function: beyond long QT
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Summary
The other functions of hERG are discussed, particularly their impact on diseases beyond cardiac arrhythmia, and their role in physiologic and pathological processes.
- Type
- review
- Published
- 2013-03-01
- Cited by
- 75
- References
- 95
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013520512
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16298304
Keywords
hERG, Long QT syndrome, Potassium channel, Repolarization, Medicine
References
- Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants.
- Expression and function of KCNH2 (HERG) in the human jejunum.
- HERG K+ currents in human prolactin-secreting adenoma cells
- Ether‐à‐go‐go‐related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons
- Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues
- HERG K+ channel, a regulator of tumor cell apoptosis and proliferation.
- herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?
- Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
- Arsenic trioxide induces the apoptosis of human breast cancer MCF-7 cells through activation of caspase-3 and inhibition of HERG channels.
- Differential expression of potassium ion channels in human renal cell carcinoma
- Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells
- Novel roles for hERG K+ channels in cell proliferation and apoptosis
- Potassium Channels, Proliferation and G1 Progression
- Erg K+ channels modulate contractile activity in the bovine epididymal duct.
- Functional Integrative Levels in the Human Interactome Recapitulate Organ Organization
- Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers.
- Glucose‐ and arginine‐induced insulin secretion by human pancreatic β‐cells: the role of HERG K+channels in firing and release
- Progesterone Impairs Human Ether-a-go-go-related Gene (HERG) Trafficking by Disruption of Intracellular Cholesterol Homeostasis*
- Expression and activity of potassium ion channels in human prostate cancer.
- Acceleration of sperm transit time and reduction of sperm reserves in the epididymis of rats exposed to sibutramine.
Cited by
- Characterization of Conserved Toxicogenomic Responses in Chemically Exposed Hepatocytes across Species and Platforms
- Mechanism of inhibition by olanzapine of cloned hERG potassium channels.
- Voltage-Gated Ion Channels in Cancer Cell Proliferation
- Ion channel profiling to advance drug discovery and development.
- Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts
- Targeting ion channels for cancer therapy by repurposing the approved drugs.
- Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels
- Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects
- Novel Bayesian classification models for predicting compounds blocking hERG potassium channels
- Targeting potassium channels in cancer
- A ligand-based virtual screening approach to identify small molecules as HERG channel activators.
- Human ether-a-go-go-related gene K(+) channels (HERG) in neurocardiology field
- Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging.
- Screening for Non-Pore Binding Modulators of EAG K+ Channels
- Development of in silico models for the prediction of toxicity incorporating ADME information
- The emerging role of in vitro electrophysiological methods in CNS safety pharmacology.
- Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay
- Effects of Temperature on Heteromeric Kv11.1a/1b and Kv11.3 Channels.
- Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels
- hERG1 potassium channel in cancer cells: a tool to reprogram immortality
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