The RAF proteins take centre stage
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Summary
A report that implicates B-RAF in human cancer has highlighted the importance of all members of this protein kinase family and recent studies have uncovered intriguing new data relating to their complex regulation and biological functions.
- Type
- review
- Published
- 2004-11-01
- Cited by
- 1,259
- References
- 99
- OpenAlex
- https://openalex.org/W2074089133
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6120763
Keywords
Effector, Gene isoform, Biology, Computational biology, Kinase
References
- Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells
- MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network.
- Phosphorylation of Raf-1 by p21-activated Kinase 1 and Src Regulates Raf-1 Autoinhibition*
- Expression of raf family proto-oncogenes in normal mouse tissues.
- Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation.
- Expression of the A-raf proto-oncogene in the normal adult and embryonic mouse.
- High-intensity Raf signals convert mitotic cell cycling into cellular growth.
- Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.
- Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling.
- A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity
- The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
- B-raf, a new member of the raf family, is activated by DNA rearrangement
- Two unrelated cell‐derived sequences in the genome of avian leukemia and carcinoma inducing retrovirus MH2.
- The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras
- A novel oncogene related to c‐mil is transduced in chicken neuroretina cells induced to proliferate by infection with an avian lymphomatosis virus.
- BRAF mutations in metastatic melanoma: a possible association with clinical outcome.
- KSR: a MAPK scaffold of the Ras pathway?
- Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.
- Endothelial apoptosis in Braf-deficient mice
- B-RAF is a therapeutic target in melanoma
Cited by
- Critical nodes in signalling pathways: insights into insulin action
- The genome and epigenome of malignant melanoma
- Pyrophosphorolysis detects B-RAF mutations in primary uveal melanoma.
- Measurement of constitutive MAPK and PI3K/AKT signaling activity in human cancer cell lines
- An investigation of the kinase dependent functions of CRaf
- Targeting protein-protein interaction by small molecules.
- Cyclic AMP (cAMP) signaling in melanocytes and melanoma.
- Functional characterization of Sl-ERF.B3, a member of the large multi-gene family of Ethylene Response Factor in tomato (Solanum lycopersicum)
- Aberrant Expression of COT Is Related to Recurrence of Papillary Thyroid Cancer
- RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
- New Compound Classes: Protein-Protein Interactions.
- Discovery of a novel pan‐RAF inhibitor with potent anti‐tumor activity in preclinical models of BRAFV600E mutant cancer
- ERK Inhibition: A New Front in the War against MAPK Pathway-Driven Cancers?
- The IGF2 mRNA binding protein p62 as a regulator of IGF2 and H19 expression - potential implications in tumorigenesis
- Mapping of signaling pathways by functional interaction proteomics.
- TR(i)P, TR(i)P, hooray : new functions for TRPC2 and TRPC3
- Effects of Dysregulated Diacylglycerol-Mediated Signaling on T Cell Function
- REGULATION OF PLATELET EXOCTOSIS AND ITS ROLE IN DISEASES
- Molecular Pathways of Cell Death and Regulation by JNK-1 and Bnip3 during Ischemia-reperfusion Injury
- Regulation of FGF Receptor signalling by SPROUTY and SPRED
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