Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity
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Summary
Induced expression of Heme Oxygenase-1 by subjecting macrophage RAW-264.7 cells to chemical or physiological hypoxia resulted in significant translocation of HO-1 protein to mitochondria, which induced mitochondrial dysfunction and mitochondrial recruitment of autophagy markers LC-3 and Drp-1.
- Type
- article
- Published
- 2013-07-23
- Cited by
- 138
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W2073819646
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17786374
Keywords
Mitochondrion, Heme oxygenase, Heme, Oxidative stress, Cell biology
References
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- Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis*
- Bilirubin is an antioxidant of possible physiological importance.
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- Heme Oxygenase-1 in Tumors
- Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain.
- Translocation of Heme Oxygenase-1 to Mitochondria Is a Novel Cytoprotective Mechanism against Non-steroidal Anti-inflammatory Drug-induced Mitochondrial Oxidative Stress, Apoptosis, and Gastric Mucosal Injury*
- Influence of buffer composition, membrane lipids and proteases on the kinetics of reconstituted cytochrome-c oxidase from bovine liver and heart.
Cited by
- Near-infrared fluorescent proteins engineered from bacterial phytochromes
- Heme oxygenase-1, a novel target for the treatment of diabetic complications: focus on diabetic peripheral neuropathy.
- The Activation and Function of Autophagy in Alcoholic Liver Disease
- Alterations in the mitochondrial responses to PENAO as a mechanism of resistance in ovarian cancer cells.
- Role of Heme Oxygenase in modulating expression of ROS-regulatory enzymes in Medicago truncatula
- Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology
- The emerging theme of redox bioenergetics in health and disease
- Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.
- ROMO1 links oxidative stress to mitochondrial integrity
- Cholesterol and metal ions in Alzheimer's disease.
- Heme biosynthesis modulation via δ-aminolevulinic acid administration attenuates chronic hypoxia-induced pulmonary hypertension.
- Redox Changes Induced by General Anesthesia in Critically Ill Patients with Multiple Traumas
- Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy
- Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)*
- The peculiarities of the structural and functional state of the cytochrome component of the liver mitochondrial respiratory chain under conditions of acetaminophen-induced hepatitis on the background of alimentary protein deprivation
- Modulation of antigen processing by haem‐oxygenase 1. Implications on inflammation and tolerance
- Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma--a review.
- HO-1 Protects against Hypoxia/Reoxygenation-Induced Mitochondrial Dysfunction in H9c2 Cardiomyocytes
- In vitro evaluation of anticancer properties of exopolysaccharides from Lactobacillus acidophilus in colon cancer cell lines
- Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344
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