Fab-PEG-Fab as a potential antibody mimetic.
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Summary
These first studies indicate that FpFs warrant further examination in a therapeutic indication where the presence of the Fc may not be required and are similar in size to an IgG antibody and about half the size of a 20 kDa PEGylated-Fab.
- Type
- article
- Published
- 2013-11-04
- Cited by
- 50
- References
- 102
- OpenAlex
- https://openalex.org/W2073180572
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206833491
Keywords
Chemistry, PEG ratio, Conjugated system, Antibody, Fragment crystallizable region
References
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- Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
- When binding is enough: nonactivating antibody formats.
- Quantifying the rebinding effect in multivalent chemical ligand-receptor systems.
- Effects of interlinker sequences on the biological properties of bispecific single-chain antibodies
- Structure-Function Studies of Two Synthetic Anti-vascular Endothelial Growth Factor Fabs and Comparison with the Avastin™ Fab*
- Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study
- INTRAOCULAR PHARMACOKINETICS AFTER A SINGLE INTRAVITREAL INJECTION OF 1.5 mg VERSUS 3.0 mg OF BEVACIZUMAB IN HUMANS
- Intramolecular complexation in aqueous solutions of an end-capped poly(ethylene glycol)
- Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity.
- Engineered antibody fragments and the rise of single domains
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- Antibody mimetics: promising complementary agents to animal-sourced antibodies
- Poly(Ethylene Glycol)-Based Backbones with High Peptide Loading Capacities
- Homogeneous Bispecifics by Disulfide Bridging
- A disulfide intercalator toolbox for the site-directed modification of polypeptides.
- Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications.
- Fc-fusion mimetics.
- Disulfide-bridging PEGylation during refolding for the more efficient production of modified proteins.
- An anti-TNF-α antibody mimetic to treat ocular inflammation
- A detergent-based procedure for the preparation of IgG-like bispecific antibodies in high yield
- Antibody Mimetics, Peptides, and Peptidomimetics.
- Ocular delivery systems for the administration of antibody therapeutics
- Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates.
- Modular Assembly of Reversible Multivalent Targeting Drug Conjugates
- Interferon dimers: IFN-PEG-IFN
- Tuning the Hydrolytic Stability of Next Generation Maleimide Cross-Linkers Enables Access to Albumin-Antibody Fragment Conjugates and tri-scFvs.
- Bioconjugation with Maleimides: A Useful Tool for Chemical Biology.
- Site-selective protein conjugation at histidine
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