Protecting p53 from degradation.
Explore this paper's citation graph
Summary
The effect of a potent activator of the p53 response, the nuclear export inhibitor leptomycin B, on Mdm2 degradation and the oligomerization ofThe p14ARF tumour suppressor and MDM2 inhibitor in response to oxidative stress are described.
- Type
- article
- Published
- 2003-04-01
- Cited by
- 16
- References
- 0
- OpenAlex
- https://openalex.org/W2072955861
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39203674
Keywords
Mdm2, DNA damage, Cancer research, Suppressor, p14arf
References
No references recorded for this paper.
Cited by
- The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies
- Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer.
- Dissection of DNA Damage Responses Using Multiconditional Genetic Interaction Maps
- NT4(Si)-p53(N15)-antennapedia induces cell death in a human hepatocellular carcinoma cell line.
- Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53
- Increased Hyaluronan Levels in HABP1/p32/gC1qR Overexpressing HepG2 Cells Inhibit Autophagic Vacuolation Regulating Tumor Potency
- Natural product-like chemical space: search for chemical dissectors of macromolecular interactions.
- Secretory Expression of p53(N15)-Ant following Lentivirus-Mediated Gene Transfer Induces Cell Death in Human Cancer Cells
- The Mdm2-p53 pathway: multiple roles in kidney development
- Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression.
- Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.
- CIRCUMVENTING CISPLATIN RESISTANCE IN OVARIAN CANCERS THROUGH REACTIVATION OF p53 BY NON-CROSS-RESISTANT PLATINUM ANALOGS
- Drug-dependent functionalization of wild-type and mutant p53 in cisplatin-resistant human ovarian tum3or cells
- Natural Product-like Scaffolds for Molecular Dissection of Macromolecular Interactions and New Therapeutic Applications
- Apoptosis in Cancer: Mechanisms, Deregulation, and Therapeutic Targeting
- NeddylatioN affects cell cycle coNtrol aNd geNome iNtegrity
Related papers
- p14ARF links the tumour suppressors RB and p53
- MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells
- The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.
- Tumor protein p53 (TP53; p53); mdm2 p53 binding protein homolog (MDM2)
- MDM2 is a central node in the p53 pathway: 12 years and counting.
- Mdm2 Regulates p53 Independently of p19ARF in Homeostatic Tissues
- Peptide activators of the p53 tumor suppressor.
- Novel Activators of the Tumour Suppressor p53
- mdm2: a bridge over the two tumour suppressors, p53 and Rb