Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea‐pig small intestine
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Summary
The findings that (−)‐Δ9‐THC and (+)‐DMH are highly potent as inhibitors of the twitch response of the mouse vas deferens and guinea‐pig myenteric plexus preparation and that DMH shows considerable stereoselectivity suggest that the inhibitory effects of cannabinoids in these preparations are mediated by cannabinoid receptors.
- Type
- article
- Published
- 1992-04-01
- Cited by
- 157
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W2072721884
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43101641
Keywords
Vas deferens, Myenteric plexus, Cannabinoid, Guinea pig, Delta-9-tetrahydrocannabinol
References
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- Cannabinoid receptor localization in brain.
- Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor.
- EFFECT OF MORPHINE ON ADRENERGIC TRANSMISSION IN THE MOUSE VAS DEFERENS. ASSESSMENT OF AGONIST AND ANTAGONIST POTENCIES OF NARCOTIC ANALGESICS
- Stereochemical effects of 11-OH-delta 8-THC-dimethylheptyl in mice and dogs.
- The non‐specific membrane binding properties of ΔA9‐tetrahydrocannabinol and the effects of various solubilizers 1
- The origin of acetylcholine released from guinea‐pig intestine and longitudinal muscle strips
- Synthesis of the individual, pharmacologically distinct, enantiomers of a tetrahydrocannabinol derivative
- Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or intrapallidal injections of enantiomeric cannabinoids.
- Structure of a cannabinoid receptor and functional expression of the cloned cDNA
- Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency.
- Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons.
- Stereospecific presynaptic inhibitory effect of delta9-tetrahydrocannabinol on cholinergic transmission in the myenteric plexus of the guinea pig.
- Aminoalkylindoles: actions on specific G-protein-linked receptors.
- Methods used for the study of opioid receptors.
- Studies of the role of membrane lipid order in the effects of delta 9-tetrahydrocannabinol on adenylate cyclase activation in heart.
Cited by
- Influence of Cannabinoids on Electrically Evoked Dopamine Release and Cyclic AMP Generation in the Rat Striatum
- Distribution of cannabinoid receptors in the central and peripheral nervous system.
- Cross-talk mechanisms between adenosine and cannabinoid receptors : implications for the effects of 9-tetrahydrocannabinol on spatial memory
- Effects of cannabinoids on neurotransmission.
- Cannabinoids and the digestive tract.
- The effect of the endopeptidase inhibitor RB38A on hippocampal expression of APP mRNA isoforms
- Drug Discovery Strategies and Methods
- Cannabis: The Genus Cannabis
- Cannabinoids for the control of experimental multiple sclerosis
- Cannabinoids may worsen gastric dysmotility induced by chronic cisplatin in the rat
- Pharmacological analysis of cannabinoid receptor activity in isolated nerve-smooth muscle and epithelial preparations
- The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212‐2 on gastrointestinal motility in the rat
- Electrically Evoked Release of [3H]Noradrenaline from Mouse Cultured Sympathetic Neurons
- Cannabinoid‐induced delayed gastric emptying is selectively increased upon intermittent administration in the rat: role of CB1 receptors
- Upregulation of CB1 receptors and agonist-stimulated [35S]GTPγS binding in the prefrontal cortex of depressed suicide victims
- Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse.
- Marijuana and Cannabinoid Research
- 1. Efecto del envejecimiento en la estructura y funcionalidad del plexo mientérico de íleon de cobayo. 2. Efecto de los cannabinoides en las alteraciones causadas por el tratamiento crónico con cisplatino en rata.
- Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice
- Pharmacological characterization of cannabinoid receptor activity in the rat‐isolated ileum myenteric plexus‐longitudinal muscle preparation
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