Drug Discovery Strategies and Methods
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Summary
This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development.
- Type
- book
- Published
- 2003-11-04
- Cited by
- 13
- References
- 748
- OpenAlex
- https://openalex.org/W616248310
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:106662649
Keywords
Drug discovery, Computer science, Computational biology, Data science, Information retrieval
References
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- The major human rhinovirus receptor is ICAM-1.
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- Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.
- SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
- Selective opioid dipeptides.
- Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
- Watching amyloid fibrils grow by time-lapse atomic force microscopy.
- Development of Polymer-Supported Benzotriazole as a Novel Traceless Linker for Solid-Phase Organic Synthesis(1).
- δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides
- First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.
- Kinetics of sickle hemoglobin polymerization. I. Studies using temperature-jump and laser photolysis techniques.
- Modeling Protein Homopolymeric Repeats: Possible Polyglutamine Structural Motifs for Huntington's Disease
- Dynamics of stromelysin/inhibitor interactions studied by 15N NMR relaxation measurements: Comparison of ligand binding to the S1-S3 and S′1-S′3 subsites
- 7 Knockouts, Transgenics, and Transplants in Prion Research
- SITES of DRUG ACTION in the HUMAN BRAIN
- The human prion diseases. A review with special emphasis on new variant CJD and comments on surveillance.
- Analysis of protein aggregation kinetics.
Cited by
- Imaging of the brain cannabinoid system.
- Studies on some Heterocyclic Entities of Therapeutic Interest
- New product development in personalised medicines: the impact of regulatory regimes
- 11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptors.
- Small-molecule microarrays: development of novel linkers and an efficient detection method for bound proteins.
- A new small-molecule Stat3 inhibitor.
- Candidate PET radioligands for cannabinoid CB1 receptors: [18F]AM5144 and related pyrazole compounds.
- Structural basis for the binding of high affinity phosphopeptides to Stat3
- A convenient approach to heterocyclic building blocks: synthesis of novel ring systems containing a [5,6]Pyrano[2,3-c]pyrazol-4(1H)-one moiety.
- Heterocycles for Alzheimer Disease: 4- and 5-Substituted Benzothiophenesas Starting Scaffold in the Construction of Potential New Inhibitors ofBACE 1
- Automatisierung komplexer chemischer Syntheseverfahren am Beispiel eines Oligosaccharid-Syntheseautomaten
- PET Imaging of Endocannabinoid System
- SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60 src (Src)
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