The interplay between infectious pancreatic necrosis virus (IPNV) and the IFN system: IFN signaling is inhibited by IPNV infection
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Summary
It is shown that addition of salmon rIFN-α1 to cells prior to IPNV infection halts the viral protein synthesis and prevents processing of pVP2 into mature VP2 and IPNV VP4 and VP5 inhibit IFN-induced expression from the Mx promoter, indicating that these proteins contribute to the antagonistic effect.
- Type
- article
- Published
- 2009-03-20
- Cited by
- 79
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2072339788
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5589529
Keywords
Infectious pancreatic necrosis virus, Biology, Virology, Interferon, Virus
References
- IPNV VP5, a novel anti-apoptosis gene of the Bcl-2 family, regulates Mcl-1 and viral protein expression.
- Infectious Pancreatic Necrosis Virus VP5 Is Dispensable for Virulence and Persistence
- Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus
- The rainbow trout (Oncorhynchus mykiss) Mx1 promoter
- Dual Luminescence-Based Reporter Gene Assay for Luciferase andβ-Galactosidase
- Synthesis of the infectious pancreatic necrosis virus polyprotein, detection of a virus-encoded protease, and fine structure mapping of genome segment A coding regions
- Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress
- Biophysical and biochemical characterization of five animal viruses with bisegmented double-stranded RNA genomes
- Cloning of the rainbow trout (Oncorhynchus mykiss) Mx2 and Mx3 cDNAs and characterization of trout Mx protein expression in salmon cells
- Identification of a Second Group of Type I IFNs in Fish Sheds Light on IFN Evolution in Vertebrates1
- A salmonid cell line (TO) for production of infectious salmon anaemia virus (ISAV).
- Effect of double-stranded RNA and interferon on the antiviral activity of Atlantic salmon cells against infectious salmon anemia virus and infectious pancreatic necrosis virus.
- Infectious pancreatic necrosis virus suppresses type I interferon signalling in rainbow trout gonad cell line but not in Atlantic salmon macrophages.
- N(pro) of classical swine fever virus is an antagonist of double-stranded RNA-mediated apoptosis and IFN-alpha/beta induction.
- The Capsid of Infectious Bursal Disease Virus Contains Several Small Peptides Arising from the Maturation Process of pVP2
- A recombinant CHSE-214 cell line expressing an Mx1 promoter-reporter system responds to both interferon type I and type II from salmonids and represents a versatile tool to study the IFN-system in teleost fish.
- Expression of interferon and interferon-induced genes in salmonids in response to virus infection, interferon-inducing compounds and vaccination.
- The nucleotide sequence of infectious pancreatic necrosis virus (IPNV) dsRNA segment A reveals one large ORF encoding a precursor polyprotein.
- Spectrophotometric method for titration of trout interferon, and its application to rainbow trout fry experimentally infected with viral haemorrhagic septicaemia virus.
- Atlantic Salmon Interferon Genes: Cloning, Sequence Analysis, Expression, and Biological Activity
Cited by
- Delayed protein shut down and cytopathic changes lead to high yields of infectious pancreatic necrosis virus cultured in Asian Grouper cells.
- In vivo study of viral haemorrhagic septicaemia virus and infectious pancreatic necrosis virus coexistence in Senegalese sole (Solea senegalensis).
- Antiviral defense in salmonids - Mission made possible?
- Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV).
- Synergistic effects in the antiviral activity of the three Mx proteins from gilthead seabream (Sparus aurata).
- Infection Profiles of Selected Aquabirnavirus Isolates in CHSE Cells
- Induction of anti-inflammatory cytokine expression by IPNV in persistent infection.
- Immunity to betanodavirus infections of marine fish.
- Establishing a cell line from Atlantic cod as a novel tool for in vitro studies.
- Infectious pancreatic necrosis virus proteins VP2, VP3, VP4 and VP5 antagonize IFNa1 promoter activation while VP1 induces IFNa1
- Study of virulence in field isolates of infectious pancreatic necrosis virus obtained from the northern part of Norway.
- Persistent infections with infectious pancreatic necrosis virus (IPNV) of different virulence in Atlantic salmon, Salmo salar L.
- Differential antiviral activity of Mx1, Mx2 and Mx3 proteins from gilthead seabream (Sparus aurata) against Infectious Pancreatic Necrosis Virus (IPNV).
- The antiviral innate immune response in fish: evolution and conservation of the IFN system.
- Characterization of an infectious pancreatic necrosis (IPN) virus carrier cell culture with resistance to superinfection with heterologous viruses.
- Evaluation of the level of Mx3 protein synthesis induced by infectious pancreatic necrosis virus (IPNV) strains of different infectivity.
- Differential response of the Senegalese sole (Solea senegalensis) Mx promoter to viral infections in two salmonid cell lines.
- Interferon Regulatory Factor-1 (IRF-1) Is Involved in the Induction of Phosphatidylserine Receptor (PSR) in Response to dsRNA Virus Infection and Contributes to Apoptotic Cell Clearance in CHSE-214 Cell
- Trout oral VP2 DNA vaccination mimics transcriptional responses occurring after infection with infectious pancreatic necrosis virus (IPNV).
- Cloning and characterization of the Mx1, Mx2 and Mx3 promoters from gilthead seabream (Sparus aurata).
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