The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome.

Keywords

Wiskott–Aldrich syndrome, Biology, Immunology, Mutant, Immunodeficiency

References

• Surface protein abnormalities in lymphocytes and platelets from patients with Wiskott-Aldrich syndrome.Robertson Parkman, DianneM. Kenney, Eileen Remold‐O’Donnell — 1981
• Report of the committee on the genetic constitution of the X chromosome.Kay E. Davies, Jean‐Louis Mandel, Anthony P. Monaco — 1988

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• Autoimmunity, Immune Deficiency and Cancer: Multiple Roles of the Protein Tyrosine Phosphate SHP-1Melissa J. Joliat — 2001
• X-linked immunodeficiencies.Jennifer M. Puck — 1993
• The molecular regulation of Forkhead box P3Simon P. Jochems — 2011
• Therapeutic Effects of Tumor Necrosis Factor Receptor Superfamily 25 (TNFRSF25)-Mediated Expansion of T-Regulatory Cells in Allergic Lung Inflammation and Airway RemodelingMatthew Tsai — 2012
• The Function of LAT in T Cell Activation and AutoimmunityMariana Chuck — 2010
• Scurfy, the Foxp3 locus, and the molecular basis of peripheral tolerance.Mark W. Appleby, Fred Ramsdell — 2008
• Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology - PrefaceBruce Beutler — 2008
• Genetics of murine lung tumors.Tommaso A. Dragani, Giacomo Manenti, Marco A. Pierotti — 1995
• The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Craig L. Bennett, Jacinda R. Christie, Fred Ramsdell — 2001
• Cellular and molecular characterization of the scurfy mouse mutant.Lisa B. Clark, Mark W. Appleby, Mary E. Brunkow — 1999
• Type-1 immunity drives early lethality in scurfy miceTodd J. Suscovich, Nikole Perdue, Daniel Campbell — 2012
• X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfyRobert S. Wildin, Fred Ramsdell, Jane Peake — 2001
• The role of TCR specificity in the regulation of the immune response to self and commensal antigensStephanie K. Lathrop — 2010
• The role of IL-27 and IL-35 in inflammatory diseases.Beilei Cai — 2008
• Antiestrogens induce TGFß-mediated immunosuppression in breast cancerChristian Joffroy — 2009
• Interleukin‐21–Producing c‐Maf–Expressing CD4+ T Cells Induce Effector CD8+ T Cells and Enhance Autoimmune Inflammation in Scurfy MiceTaro Iwamoto, Akira Suto, Shigeru Tanaka — 2014
• Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseMary E. Brunkow, Eric W. Jeffery, Kathryn A. Hjerrild — 2001
• Immunodeficiencies with autoimmune consequences.Luigi D. Notarangelo, Eleonora Gambineri, Raffaele Badolato — 2006

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• Prenatal Diagnosis and Genetic Analysis of X-Linked Immunodeficiency DisordersJennifer M. Puck — 1993