Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes
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Summary
The results show that carbachol stimulates DNA synthesis via muscarinic acetylcholine receptors (mAChRs), in primary astrocytes derived from perinatal rat brain, in an age-dependent fashion, and indicate that the specificity of acetylCholine-induced cell proliferation may be determined by the expression of those mAChR subtypes which activate PI hydrolysis.
- Type
- article
- Published
- 1989-07-13
- Cited by
- 243
- References
- 32
- OpenAlex
- https://openalex.org/W2071785245
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4312544
Keywords
Muscarinic acetylcholine receptor, Carbachol, Acetylcholine, Chinese hamster ovary cell, Cell biology
References
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Cited by
- Functional and molecular characterization of a muscarinic receptor type and evidence for expression of choline-acetyltransferase and vesicular acetylcholine transporter in human granulosa-luteal cells.
- Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes.
- Muscarinic Receptor Agonists and Antagonists: Effects on Cancer
- Muscarinic cholinergic signaling and overactive bladder-like symptoms associated with invasive bladder cancer
- Expression of Lysophosphatidic Acid Receptor in Rat Astrocytes: Mitogenic Effect and Expression of Neurotrophic Genes
- A dopamine D3 receptor genotype is associated with hyperandrogenic chronic anovulation and resistant to ovulation induction with clomiphene citrate in female Hispanics.
- Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
- Effects of Nicotine on Biological Systems II
- Alcohol, Cell Membranes, and Signal Transduction in Brain
- G protein-controlled signal transduction pathways and the regulation of cell proliferation.
- Expression and in vivo amplification of the human acetylcholinesterase and butyrylcholinesterase genes.
- The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action.
- Characterization of muscarinic receptors in human lens cells by pharmacologic and molecular techniques.
- Acetylcholine stimulates cortical precursor cell proliferation in vitro via muscarinic receptor activation and MAP kinase phosphorylation
- Pharmacological and functional characterization of muscarinic receptor subtypes in developing oligodendrocytes
- Neurotransmitters as neurotrophic factors: a new set of functions.
- Differential intracellular calcium responses to glutamate in type 1 and type 2 cultured brain astrocytes
- Transcription of the M1 muscarinic receptor gene in neurons and neuronal progenitors of the embryonic rat forebrain
- Nuclear muscarinic acetylcholine receptors in corneal cells from rabbit.
- Cholinergic regulation of [Ca2+]i during cell division and differentiation in the mammalian retina
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