Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes

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Summary

The results show that carbachol stimulates DNA synthesis via muscarinic acetylcholine receptors (mAChRs), in primary astrocytes derived from perinatal rat brain, in an age-dependent fashion, and indicate that the specificity of acetylCholine-induced cell proliferation may be determined by the expression of those mAChR subtypes which activate PI hydrolysis.

Type
article
Published
1989-07-13
Cited by
243
References
32

Keywords

Muscarinic acetylcholine receptor, Carbachol, Acetylcholine, Chinese hamster ovary cell, Cell biology

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