Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance.
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Summary
An important role for iNOS is demonstrated in LPS-induced insulin resistance, evidenced by the attenuation of LPS -induced hyperglycemia and reversal of increased hepatic glucose output by aminoguanidine.
- Type
- article
- Published
- 2002-02-01
- Cited by
- 141
- References
- 60
- OpenAlex
- https://openalex.org/W2071741172
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11115443
Keywords
Glycogenolysis, Internal medicine, Phosphoenolpyruvate carboxykinase, Endocrinology, Insulin resistance
References
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- Endotoxin and fibrinogen degradation product‐D have different actions on carbohydrate metabolism: role of Kupffer cells
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- Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat.
Cited by
- Microsomal glutathione transferase 1 is not S-nitrosylated in rat liver microsomes or in endotoxin challenged rats.
- Deletion of Inducible Nitric-Oxide Synthase in Leptin-Deficient Mice Improves Brown Adipose Tissue Function
- The function of miRNAs and their potential as therapeutic targets in burn-induced insulin resistance (review).
- The effects of LPS plus pro-inflammatory cytokines on glycogen synthesis in C2C12 myocytes
- Effects of bacterial infection on insulin secretory capacity of human adult pancreatic islets
- Short-term effects of thalidomide analogs on hepatic glycogen and nitric oxide in endotoxin-challenged rats.
- Effects of an acute bout of moderate-intensity exercise on postprandial lipemia and airway inflammation.
- Hemodynamic and metabolic actions of Adiponectin in muscle
- Examining the Acute and Chronic Effects of Sepsis on the Circadian Clock in the Mouse
- Hormokines : a novel concept of plasticity in neuro-endo-immunology
- Sepsis beim Hund: Interleukin-6 als prognostischer Parameter
- Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese
- Nitric oxide mediates the insulin sensitizing effects of β-sitosterol in high fat diet-fed rats.
- Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier.
- Insulin sensitivity and resistin expression in nitric oxide-deficient rats
- Impaired Liver Glucose Production in a Murine Model of Steatosis and Endotoxemia: Protection by Inducible Nitric Oxide Synthase
- Substrate utilization in sepsis and multiple organ failure.
- IKK-β links inflammation to obesity-induced insulin resistance
- Glucose modulates Pax6 expression through the JNK/p38 MAP kinase pathway in pancreatic beta-cells.
- Suppression of inducible nitric oxide synthase expression and amelioration of lipopolysaccharide-induced liver injury by polyphenolic compounds in Eucalyptus globulus leaf extract
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