Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
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Summary
The data suggest that increased expression of S-100 in Down syndrome, resulting from duplication of the gene on chromosome 21 that encodes the beta subunit ofS-100, may be augmented by elevation of interleukin 1, which may promote the astrogliosis in Alzheimer disease.
- Type
- article
- Published
- 1989-10-01
- Cited by
- 1,813
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W2071695496
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14980523
Keywords
Astrogliosis, Glial fibrillary acidic protein, Alzheimer's disease, Astrocyte, Down syndrome
References
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- Fibrous Astrocytes in Senile Dementia of the Alzheimer Type
- The postmortem Alzheimer brain is a source of structurally and functionally intact astrocytic messenger RNA.
Cited by
- The S-100: a protein family in search of a function.
- Effect of growth factors and cytokines on expression of amyloid beta protein precursor mRNAs in cultured neural cells.
- Induction of NF‐kB‐like transcription factors in brain areas susceptible to kainate toxicity
- Oxidative damage and fibrogenesis.
- Induction of Stat3, a Signal Transducer and Transcription Factor, in Reactive Microglia following Transient Focal Cerebral Ischaemia
- Murine models of brain aging and age-related neurodegenerative diseases.
- Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain.
- S100B: Pathogenetische und pathophysiologische Bedeutung in der Neurologie
- What is the biological significance of an age-related increase in IL-1β in hippocampus?
- Cytokine involvement in dynorphin‐induced allodynia
- Decreased Levels of Intrathecal Interleukin 1 Receptor Antagonist in Alzheimer’s Disease
- Inflammatory markers in Alzheimer's disease and multi-infarct dementia.
- Apoptotic Changes in the Aged Brain Are Triggered by Interleukin-1β-induced Activation of p38 and Reversed by Treatment with Eicosapentaenoic Acid*
- APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.
- Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration.
- S100 beta as a neurotrophic factor.
- Lack of Association of the Interleukin-1β Gene Polymorphism with Alzheimer’s Disease in a Chinese Population
- Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation.
- Trisomy 21 and the Brain
- Effects of Chronic Administration with Nilvadipine Against Immunohistochemical Changes Related to Aging in the Mouse Hippocampus
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